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The effect of insulin feedback on closed loop glucose control.

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The effect of insulin feedback on closed loop glucose control.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Voskanyan, Gayane Palerm, Cesar C. Kandeel, Fouad R. Kurtz, Natalie Steil, Garry M. Paz, Sachiko Roy, Anirban
Description	Country affiliation: United States Author Affiliation: Steil GM ( Children's Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA. garry.steil@childrens.harvard.edu)
Abstract	CONTEXT: Initial studies of closed-loop proportional integral derivative control in individuals with type 1 diabetes showed good overnight performance, but with breakfast meal being the hardest to control and requiring supplemental carbohydrate to prevent hypoglycemia. OBJECTIVE: The aim of this study was to assess the ability of insulin feedback to improve the breakfast-meal profile. DESIGN AND SETTING: We performed a single center study with closed-loop control over approximately 30 h at an inpatient clinical research facility. PATIENTS: Eight adult subjects with previously diagnosed type 1 diabetes participated. INTERVENTION: Subjects received closed-loop insulin delivery with supplemental carbohydrate as needed. MAIN OUTCOME MEASURES: Outcome measures were plasma insulin concentration, model-predicted plasma insulin concentration, 2-h postprandial and 3- to 4-h glucose rate-of-change following breakfast after 1 d of closed-loop control, and the need for supplemental carbohydrate in response to nadir hypoglycemia. RESULTS: Plasma insulin levels during closed loop were well correlated with model predictions (R = 0.86). Fasting glucose after 1 d of closed loop was not different from nighttime target (118 ± 9 vs. 110 mg/dl; P = 0.38). Two-hour postbreakfast glucose was 132 ± 16 mg/dl with stable values 3-4 h after the meal (0.03792 ± 0.0884 mg/dl · min, not different from 0; P = 0.68) and at target (97 ± 6 mg/dl, not different from 90; P = 0.28). Three subjects required supplemental carbohydrates after breakfast on d 2 of closed loop. CONCLUSIONS/INTERPRETATION: Insulin feedback can be implemented using a model estimate of concentration. Proportional integral derivative control with insulin feedback can achieve a desired breakfast response but still requires supplemental carbohydrate to be delivered in some instances. Studies assessing more optimal control configurations and safeguards need to be conducted.
ISSN	0021972X
e-ISSN	19457197
DOI	10.1210/jc.2010-2578
Journal	The Journal of Clinical Endocrinology & Metabolism
Issue Number	5
Volume Number	96
Language	English
Publisher	Oxford University Press
Publisher Date	2011-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Blood Glucose Metabolism Diabetes Mellitus, Type 1 Drug Therapy Feedback, Physiological Physiology Hypoglycemic Agents Therapeutic Use Insulin Algorithms Biosensing Techniques Calibration Dietary Carbohydrates Hypoglycemia Administration & Dosage Blood Models, Biological Postprandial Period Research Support, N.i.h., Extramural Discipline Endocrinology Discipline Metabolism
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Clinical Biochemistry Biochemistry Endocrinology

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