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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Beretta, M. Barberio, C. Ranzani, G. Negri, M. Antonini, G. Cavalli-Sforza, L. L. Modiano, G. Santachiara-Benerecetti, A. S. |
| Spatial Coverage | Cameroon Central African Republic Democratic Republic of the Congo |
| Abstract | In the course of a long-term research project, three groups of Pygmies and some non-Pygmy Central Africans have been examined for the following red cell enzyme markers: ACP, PGM1, PGM2, PEPA, PEPB, and PEPC, AK, ADA, and PHI. Several other red cell enzymes (ESD, CA1 and CA2, GPT, GLO, and DIA1) have been studied in only some of these groups. This paper reports all the information we obtained, including what we have already published. The following conclusions can be drawn from the whole body of data: (1) Gene patterns of Pygmies are those typical of other Africans (e.g.: lack of ADA2 and AK2 genes, low GPT2 gene frequency, polymorphism of the CA2 locus, and presence at polymorphic frequencies of PEPA2 allele. (2) Superimposed on this African genetic makeup, a number of Pygmy characters were identified, namely, a private polymorphism for the PGM26 Pygmy allele and possibly one for the PEPC2 allele, and particularly high ACPR and low PGM12 gene frequencies. (3) Some markers, especially PGM1 and ACP, turned out also to discriminate efficiently among different groups of Pygmies. |
| ISSN | 00029297 |
| e-ISSN | 15376605 |
| Journal | The American Journal of Human Genetics |
| Issue Number | 6 |
| Volume Number | 32 |
| Language | English |
| Publisher | Cell Press (on behalf of American Society of Human Genetics) |
| Publisher Date | 1980-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | African Continental Ancestry Group Erythrocytes Enzymology Cameroon Central African Republic Democratic Republic Of The Congo Ethnic Groups Gene Frequency Genetic Markers Polymorphism, Genetic Comparative Study Research Support, Non-u.s. Gov't Discipline Human Genetics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Genetics (clinical) |
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