NDLI: Maternal-age effect in aneuploidy: does altered embryonic selection play a role?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lippman-Hand, A. Aymé, S.
Abstract	The age of mothers of children with trisomy 21 (47,+21) is elevated no matter if the extra chromosome is of maternal or paternal origin, and it has been postulated that decreasing maternal selection against affected conceptuses with advancing age might explain this observation. Since the absence of sufficient data on 47,+21 abortuses precludes a direct test of this hypothesis, we have taken an indirect approach. Pooled data from spontaneous abortions and live births with autosomal trisomies, XXY and XXX, were examined to determine the natural history of these aneuploid conceptuses and its relation to maternal age. The results are consistent with decreasing embryonic selection in older women.
ISSN	00029297
e-ISSN	15376605
Journal	The American Journal of Human Genetics
Issue Number	4
Volume Number	34
Language	English
Publisher	Cell Press (on behalf of American Society of Human Genetics)
Publisher Date	1982-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aneuploidy Maternal Age Abortion, Spontaneous Genetics Adolescent Down Syndrome Meiosis Pregnancy Probability Trisomy Discipline Human Genetics
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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Maternal-age effect in aneuploidy: does altered embryonic selection play a role?