NDLI: Prenatal hemoglobinopathy screening. IV. Follow-up of women at risk for a child with a clinically significant hemoglobinopathy.

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Prenatal hemoglobinopathy screening. IV. Follow-up of women at risk for a child with a clinically significant hemoglobinopathy.

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Regional mapping of the Batten disease locus (CLN3) to human chromosome 16p12.

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Molecular definition of the shortest region of deletion overlap in the Langer-Giedion syndrome.

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Prenatal hemoglobinopathy screening. IV. Follow-up of women at risk for a child with a clinically significant hemoglobinopathy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rowley, P. T. Segelman, S. G. Loader, S. Kozyra, A. Sutera, C. J.
Description	Author Affiliation: Loader S ( Department of Medicine, University of Rochester School of Medicine, NY 14642.)
Abstract	To determine the benefits and burdens of prenatal hemoglobinopathy carrier identification and genetic counseling and its impact on subsequent reproductive behavior, we recontacted women whom we had previously identified as at risk for having a child with a clinically significant hemoglobinopathy, regardless of whether they had accepted the offer of prenatal diagnosis. Of the 46 such women, 31 were available for interview. These 31 women had received offers of prenatal diagnosis in 47 pregnancies. Seventeen had been accepted, and 30 had been declined. The proportion of patients accepting the offer of prenatal diagnosis was higher for the index pregnancy (50%) than for subsequent pregnancies (22%). The mean interval between the initial counseling of the patient and the follow-up interview was 43 mo (standard error +/- 2.7 mo). Ninety-four percent of those interviewed recalled having received information from the screening program; 74% recalled the name of their condition; 90% knew that trait did not affect their health; 84% recalled the name of the condition for which their fetus had been at risk; and 77% could state at least one symptom of the disease. Of the 29 women asked whether they intended to use prenatal diagnosis in future pregnancies, 13 said yes and 16 said no. Of the 26 patients asked about satisfaction with their previous decision about prenatal diagnosis, all were satisfied with their decision. Eighteen said they would make the same decision in their next pregnancy, but seven patients said they would not, and one was undecided.(ABSTRACT TRUNCATED AT 250 WORDS)
ISSN	00029297
e-ISSN	15376605
Journal	The American Journal of Human Genetics
Issue Number	6
Volume Number	49
Language	English
Publisher	Cell Press (on behalf of American Society of Human Genetics)
Publisher Date	1991-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Hemoglobinopathies Genetics Prenatal Diagnosis Adolescent Attitude To Health Decision Making Genetic Counseling Diagnosis Psychology Interviews As Topic Patient Satisfaction Pregnancy Reproducibility Of Results Risk Factors Sexual Behavior Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, P.h.s. Discipline Human Genetics
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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