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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lekanne Deprez, R. H. Koper, J. W. Bootsma, D. Kley, N. Van Drunen, E. Bianchi, A. B. Seizinger, B. R. Hagemeijer, A. Avezaat, C. J. Groen, N. A. |
| Description | Country affiliation: Netherlands Author Affiliation: Lekanne Deprez RH ( Department of Pathology, Erasmus University, Rotterdam, The Netherlands.) |
| Abstract | The gene for the hereditary disorder neurofibromatosis type 2 (NF2), which predisposes for benign CNS tumors such as vestibular schwannomas and meningiomas, has been assigned to chromosome 22 and recently has been isolated. Mutations in the NF2 gene were found in both sporadic meningiomas and vestibular schwannomas. However, so far only 6 of the 16 exons of the gene have been analyzed. In order to extend the analysis of an involvement of the NF2 gene in the sporadic counterparts of these NF2-related tumors, we have used reverse transcriptase-PCR amplification followed by SSCP and DNA sequence analysis to screen for mutations in the coding region of the NF2 gene. Analysis of the NF2 gene transcript in 53 unrelated patients with meningiomas and vestibular schwannomas revealed mutations in 32% of the sporadic meningiomas (n = 44), in 50% of the sporadic vestibular schwannomas (n = 4), in 100% of the tumors found in NF2 patients (n = 2), and in one of three tumors from multiple-meningioma patients. Of the 18 tumors in which a mutation in the NF2 gene transcript was observed and the copy number of chromosome 22 could be established, 14 also showed loss of (parts of) chromosome 22. This suggests that in sporadic meningiomas and NF2-associated tumors the NF2 gene functions as a recessive tumor-suppressor gene. The mutations detected resulted mostly in frameshifts, predicting truncations starting within the N-terminal half of the putative protein. |
| ISSN | 00029297 |
| e-ISSN | 15376605 |
| Journal | The American Journal of Human Genetics |
| Issue Number | 6 |
| Volume Number | 54 |
| Language | English |
| Publisher | Cell Press (on behalf of American Society of Human Genetics) |
| Publisher Date | 1994-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Genes, Neurofibromatosis 2 Genetics Meningeal Neoplasms Meningioma Mutation Neurofibromatosis 2 Chromosome Deletion Chromosomes, Human, Pair 22 Dna Mutational Analysis In Situ Hybridization, Fluorescence Karyotyping Molecular Sequence Data Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Rna, Messenger Rna, Neoplasm Transcription, Genetic Research Support, Non-u.s. Gov't Discipline Human Genetics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Genetics (clinical) |
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