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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cannings, C. |
| Description | Country affiliation: United kingdom Author Affiliation: Cannings C ( School of Mathematics and Statistics, University of Sheffield, Sheffield, United Kingdom. c.cannings@sheffield.ac.uk) |
| Abstract | Génin and Clerget-Darpoux recently discussed the derivation of the probabilities of identity states for populations in which there was some degree of kinship, primarily to allow the extension of the classical affected-sib-pair method to such populations. It is argued here that their derivation makes certain assumptions that are valid only for some very restricted population models and that are not needed for an appropriate treatment. Here the probabilities of the identity states of two individuals with a given genealogical relationship are specified in terms of the kinship parameters of the underlying population, from which the founders of the individuals' genealogy have been randomly selected. It is argued that an appropriate representation for a permutable population, one in which gene identity does not depend on the pattern of genes across individuals, requires three parameters. This representation is related to that of Génin and Clerget-Darpoux and to that of Weir. |
| ISSN | 00029297 |
| e-ISSN | 15376605 |
| Journal | The American Journal of Human Genetics |
| Issue Number | 3 |
| Volume Number | 62 |
| Language | English |
| Publisher | Cell Press (on behalf of American Society of Human Genetics) |
| Publisher Date | 1998-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Genetics, Population Probability Models, Genetic Discipline Human Genetics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Genetics (clinical) |
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