NDLI: Individual estimates of European genetic admixture associated with lower body-mass index, plasma glucose, and prevalence of type 2 diabetes in Pima Indians.

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Individual estimates of European genetic admixture associated with lower body-mass index, plasma glucose, and prevalence of type 2 diabetes in Pima Indians.

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Individual estimates of European genetic admixture associated with lower body-mass index, plasma glucose, and prevalence of type 2 diabetes in Pima Indians.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Williams, R. C. Knowler, W. C. Hanson, R. L. Long, J. C. Sievers, M. L.
Spatial Coverage	Europe
Description	Author Affiliation: Williams RC ( Department of Anthropology, Arizona State University, Box 872402, Tempe, AZ 85287-2402, USA. rcw@delphos.la.asu.edu. rcw@delphos.la.asu.edu)
Abstract	Individual genetic admixture estimates (IA) from European Americans (EAs) were computed in 7,996 members of the Gila River Indian Community (Arizona). Parental populations for the analysis were European Americans and full-heritage Pima Indians. A logistic regression was performed on 7,796 persons, to assess association of IA with type 2 diabetes. The odds ratio, comparing diabetes risk in full-heritage EAs with full-heritage Pima Indians, was 0.329 (95% confidence interval [CI] 0.225-0.482). Proportional-hazards analysis was performed on 5,482 persons who were nondiabetic at their first examination and 1,215 subjects who developed diabetes during the study. The hazard risk ratio for IA was 0.455 (95% CI 0.301-0.688). Nondiabetic persons had significantly more European IA. In nondiabetic Pimans, multivariate linear regressions of quantitative predictors of type 2 diabetes mellitus, including fasting plasma glucose, 2-h post-load plasma glucose, and body-mass index, showed significant inverse relations with IA when controlled for sex and age. These results illustrate the ongoing evolution of populations by the mechanism of gene flow and its effect on disease risk in the groups with admixture. When the two parental populations differ in disease prevalence, higher or lower risk is associated with admixture, depending on the origin of the admixed alleles and the relative magnitude of the disease prevalence in the parental populations. These data also illustrate the strong genetic components in type 2 diabetes and are consistent with one susceptibility locus common to obesity and diabetes.
ISSN	00029297
e-ISSN	15376605
Journal	The American Journal of Human Genetics
Issue Number	2
Volume Number	66
Language	English
Publisher	Cell Press (on behalf of American Society of Human Genetics)
Publisher Date	2000-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Blood Glucose Genetics Body Mass Index Diabetes Mellitus, Type 2 Genetic Predisposition To Disease Indians, North American Obesity Alleles Epidemiology Ethnology Fasting Gene Frequency Genetic Variation Logistic Models Odds Ratio Proportional Hazards Models Sex Factors Research Support, Non-u.s. Gov't Discipline Human Genetics
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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