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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lancet, Doron Pääbo, Svante Gilad, Yoav Bustamante, Carlos D. |
| Description | Country affiliation: Germany Author Affiliation: Gilad Y ( Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany. gilad@eva.mpg.de) |
| Abstract | The olfactory receptor (OR) genes constitute the largest gene family in mammalian genomes. Humans have >1,000 OR genes, of which only approximately 40% have an intact coding region and are therefore putatively functional. In contrast, the fraction of intact OR genes in the genomes of the great apes is significantly greater (68%-72%), suggesting that selective pressures on the OR repertoire vary among these species. We have examined the evolutionary forces that shaped the OR gene family in humans and chimpanzees by resequencing 20 OR genes in 16 humans, 16 chimpanzees, and one orangutan. We compared the variation at the OR genes with that at intergenic regions. In both humans and chimpanzees, OR pseudogenes seem to evolve neutrally. In chimpanzees, patterns of variability are consistent with purifying selection acting on intact OR genes, whereas, in humans, there is suggestive evidence for positive selection acting on intact OR genes. These observations are likely due to differences in lifestyle, between humans and great apes, that have led to distinct sensory needs. |
| ISSN | 00029297 |
| e-ISSN | 15376605 |
| Journal | The American Journal of Human Genetics |
| Issue Number | 3 |
| Volume Number | 73 |
| Language | English |
| Publisher | Cell Press (on behalf of American Society of Human Genetics) |
| Publisher Date | 2003-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Multigene Family Pan Troglodytes Genetics Receptors, Odorant Selection, Genetic Animals Molecular Sequence Data Research Support, Non-u.s. Gov't Discipline Human Genetics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Genetics (clinical) |
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