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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Boehringer, Stefan McMaster, Mary L. Ter-Minassian, Monica Vasquez, Linda G. Giambarresi, Therese R. Bai, Yan Goldin, Lynn R. Tucker, Margaret A. |
| Description | Country affiliation: United States Author Affiliation: McMaster ML ( Genetic Epidemiology Branch, Bethesda, MD, 20892-7236, USA. mcmastem@mail.nih.gov) |
| Abstract | Waldenstrom macroglobulinemia (WM), a distinctive subtype of non-Hodgkin lymphoma that features overproduction of immunoglobulin M (IgM), clearly has a familial component; however, no susceptibility genes have yet been identified. We performed a genomewide linkage analysis in 11 high-risk families with WM that were informative for linkage, for a total of 122 individuals with DNA samples, including 34 patients with WM and 10 patients with IgM monoclonal gammopathy of undetermined significance (IgM MGUS). We genotyped 1,058 microsatellite markers (average spacing 3.5 cM), performed both nonparametric and parametric linkage analysis, and computed both two-point and multipoint linkage statistics. The strongest evidence of linkage was found on chromosomes 1q and 4q when patients with WM and with IgM MGUS were both considered affected; nonparametric linkage scores were 2.5 (P=.0089) and 3.1 (P=.004), respectively. Other locations suggestive of linkage were found on chromosomes 3 and 6. Results of two-locus linkage analysis were consistent with independent effects. The findings from this first linkage analysis of families at high risk for WM represent important progress toward identifying gene(s) that modulate susceptibility to WM and toward understanding its complex etiology. |
| ISSN | 00029297 |
| e-ISSN | 15376605 |
| Journal | The American Journal of Human Genetics |
| Issue Number | 4 |
| Volume Number | 79 |
| Language | English |
| Publisher | Cell Press (on behalf of American Society of Human Genetics) |
| Publisher Date | 2006-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Genetic Predisposition To Disease Genome, Human Waldenstrom Macroglobulinemia Genetics Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 4 Lod Score Microsatellite Repeats Models, Genetic Pedigree Research Support, N.i.h., Extramural Research Support, N.i.h., Intramural Discipline Human Genetics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Genetics (clinical) |
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