NDLI: Endovascular treatment of unruptured intracranial aneurysms with Guglielmi detachable coils: short- and long-term results of a single-centre series.

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Endovascular treatment of unruptured intracranial aneurysms with Guglielmi detachable coils: short- and long-term results of a single-centre series.

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Endovascular treatment of unruptured intracranial aneurysms with Guglielmi detachable coils: short- and long-term results of a single-centre series.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Knosp, Engelbert Bavinzski, Gerhard Standhardt, Harald Gruber, Andreas Benesch, Thomas Boecher-Schwarz, Hans
Description	Country affiliation: Austria Author Affiliation: Standhardt H ( Department of Neurosurgery, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria. harald.standhardt@meduniwien.ac.at)
Abstract	BACKGROUND AND PURPOSE: Purpose of the present study is to evaluate the clinical outcome of endovascular treatment of unruptured intracranial aneurysms and to address the question of long-term stability and protection against future subarachnoid hemorrhage. METHODS: Retrospective analysis of all patients treated in a 12-year period (173 patients: age 26 to 76 yr, mean 52.2+/-10.8/202 aneurysms: size 3 to 50 mm, mean 10.0+/-8.3). RESULTS: The mortality was 0.5%; the overall morbidity was 3.5%. The most frequent complications were thromboembolic events (10.9%). Of these, 3.0% of patients suffered a stroke, leading to severe disability in 1 patient (0.5%). In 1 patient, the aneurysm ruptured during treatment, resulting in relevant neurological disability. Another patient suffered a fatal aneurysm rupture hours after treatment. The occlusion rate depended on aneurysm and neck size. Follow-up angiography revealed a decrease of the occlusion rate over time. This trend was obvious in all size categories and was most pronounced in giant aneurysms. In 3 patients (1.5%) with partially thrombosed giant aneurysms of the posterior circulation, embolization could not prevent later aneurysm rupture. There were no ruptures of any other aneurysms in the follow-up period (3.7+/-3.4 yr). CONCLUSIONS: Endovascular treatment is a highly safe procedure with low intervention-related morbidity and mortality. Long-term data for nongiant aneurysms showed good protection against rupture in the observation period. In contrast, the risk of rupture for giant aneurysms of the posterior circulation was as high as expected in observational studies.
ISSN	00392499
e-ISSN	15244628
Journal	Stroke
Issue Number	3
Volume Number	39
Language	English
Publisher	Lippincott Williams & Wilkins (on behalf of the American Heart Association)
Publisher Date	2008-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Embolization, Therapeutic Intracranial Aneurysm Therapy Aneurysm, Ruptured Complications Etiology Mortality Cerebral Angiography Adverse Effects Instrumentation Nervous System Diseases Retrospective Studies Stroke Thromboembolism Discipline Cardiology
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine Neuroscience Advanced and Specialized Nursing Neurology (clinical)

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