NDLI: VEGF receptor-2 variants are associated with susceptibility to stroke and recurrence.

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VEGF receptor-2 variants are associated with susceptibility to stroke and recurrence.

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VEGF receptor-2 variants are associated with susceptibility to stroke and recurrence.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Weili Chen, Jinxing Zhen, Yisong Sun, Kai Xu, Jianfeng Hui, Rutai Wang, Daowen Wang, Yibo Hu, Frank B.
Description	Author Affiliation: Zhang W ( Cardiovascular Institute and FuWai Hospital, Chinese Academy of Medical Sciences, 167 Beilishilu, Beijing 100037, PR China.)
Abstract	BACKGROUND AND PURPOSE: Dysregulation of vessel wall formation, growth, and maintenance may confer susceptibility of stroke. METHODS: We tested the hypothesis that variants in 2 genes encoding vascular endothelial growth factor and vascular endothelial growth factor receptor-2 are associated with susceptibility to stroke and its recurrence in a Chinese case-control study comprising 1849 patients with stroke and 1798 control subjects and replicated the investigation in an independent study comprising 327 cases and 327 control subjects. The correlation of variants with carotid artery intima media thickness was examined in 1123 healthy individuals. RESULTS: Compared with their corresponding wild-type genotypes, one coding variant, rs2305948 (Val297Ile), in the vascular endothelial growth factor receptor-2 gene was associated with increased susceptibility to intracerebral hemorrhage (additive model: OR, 2.06; 95% CI, 1.64 to 2.59; P=7.6x10(-10); dominant model: OR, 2.20; 95% CI, 1.70 to 2.84; P=1.5x10(-9)), a promoter variant rs2071559 (-604T>C) in the gene was associated with reduced susceptibility to atherothrombotic stroke (additive model: OR, 0.82; 95% CI, 0.71 to 0.93; P=0.003; dominant model: OR, 0.78; 95% CI, 0.65 to 0.92; P=0.004) and was reversely correlated with carotid artery intima media thickness (P=2.8x10(-5)). Replication in the second study yielded similar results. During a median 4.5 years of follow-up for the first stroke population, 355 recurrent strokes were documented. Subjects carrying 297Ile had a higher risk for stroke recurrence (relative risk, 1.40; 95% CI, 1.12 to 1.75; P=0.003), and those with -604C had a lower risk for recurrence (relative risk, 0.71; 95% CI, 0.58 to 0.89; P=0.002) than their wild-type carriers. CONCLUSIONS: The vascular endothelial growth factor receptor-2 gene variants may serve as novel genetic markers for the risk of stroke and its recurrence.
ISSN	00392499
e-ISSN	15244628
Journal	Stroke
Issue Number	8
Volume Number	40
Language	English
Publisher	Lippincott Williams & Wilkins (on behalf of the American Heart Association)
Publisher Date	2009-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Genetic Predisposition To Disease Genetic Variation Genetics Stroke Vascular Endothelial Growth Factor Receptor-2 Case-control Studies Genetic Markers Models, Genetic Prospective Studies Secondary Prevention Metabolism Prevention & Control Biosynthesis Chemistry Comparative Study Multicenter Study Research Support, Non-u.s. Gov't Discipline Cardiology
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine Neuroscience Advanced and Specialized Nursing Neurology (clinical)

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