NDLI: A new therapeutic strategy for acute ischemic stroke: sequential combined intravenous tPA-tenecteplase for proximal middle cerebral artery occlusion based on first results in 13 consecutive patients.

Please wait, while we are loading the content...

Year: 2017 Volume: 48

Year: 2016 Volume: 47

Year: 2015 Volume: 46

Year: 2014 Volume: 45

Year: 2013 Volume: 44

Year: 2012 Volume: 43

Year: 2011 Volume: 42

Year: 2011 Volume: 42 Issue: 12

Year: 2011 Volume: 42 Issue: 11

Year: 2011 Volume: 42 Issue: 10

Year: 2011 Volume: 42 Issue: 9

Year: 2011 Volume: 42 Issue: 8

Year: 2011 Volume: 42 Issue: 7

Year: 2011 Volume: 42 Issue: 6

Stroke unit care combined with early supported discharge improves 5-year outcome: a randomized controlled trial.

Is the Montreal Cognitive Assessment superior to the Mini-Mental State Examination to detect poststroke cognitive impairment? A study with neuropsychological evaluation.

The importance of size: successful recanalization by intravenous thrombolysis in acute anterior stroke depends on thrombus length.

Adiponectin level as a consequence of genetic variation, but not leptin level or leptin: adiponectin ratio, is a risk factor for carotid intima-media thickness.

Safety and outcomes of intravenous thrombolysis in stroke mimics: a 6-year, single-care center study and a pooled analysis of reported series.

Patient outcomes with endovascular embolectomy therapy for acute ischemic stroke: a study of the national inpatient sample: 2006 to 2008.

Paradoxical trends in the management of unruptured cerebral aneurysms in the United States: analysis of nationwide database over a 10-year period.

High NIHSS values predict impairment of cardiovascular autonomic control.

Improving stroke risk stratification using the CHADS2 and CHA2DS2-VASc risk scores in patients with paroxysmal atrial fibrillation by continuous arrhythmia burden monitoring.

Is the maximum dose of 90 mg alteplase sufficient for patients with ischemic stroke weighing >100 kg?

Surgical revascularization reverses cerebral cortical thinning in patients with severe cerebrovascular steno-occlusive disease.

Burden of stroke in indigenous Western Australians: a study using data linkage.

A phase II multicentered, single-blind, randomized, controlled trial of the stroke self-management program.

Excess risk of stroke in Australia's Aboriginal and Torres Strait Islander populations.

The weight of tissue plasminogen activator dose in overweight patients with strokes.

Global cerebral edema and brain metabolism after subarachnoid hemorrhage.

Effects of continuous hypertonic saline infusion on perihemorrhagic edema evolution.

A topographic study of the evolution of the MR DWI/PWI mismatch pattern and its clinical impact: a study by the EPITHET and DEFUSE Investigators.

Endovascular treatment of tandem extracranial/intracranial anterior circulation occlusions: preliminary single-center experience.

Association of early National Institutes of Health Stroke Scale improvement with vessel recanalization and functional outcome after intravenous thrombolysis in ischemic stroke.

Hemorrhage risk of cerebral arteriovenous malformations before and during the latency period after GAMMA knife radiosurgery.

Letter by Lin et al regarding article, 'Hepatitis C virus infection and increased risk of cerebrovascular disease'.

Association with serum gamma-glutamyltransferase levels and alcohol consumption on stroke and coronary artery disease: the Suita study.

Reliability of prehospital real-time cellular video phone in assessing the simplified National Institutes Of Health Stroke Scale in patients with acute stroke: a novel telemedicine technology.

Dietary intakes of antioxidant vitamins and mortality from cardiovascular disease: the Japan Collaborative Cohort Study (JACC) study.

Using recombinant tissue plasminogen activator to treat acute ischemic stroke in China: analysis of the results from the Chinese National Stroke Registry (CNSR).

Predicting infarction within the diffusion-weighted imaging lesion: does the mean transit time have added value?

Cost effectiveness of warfarin versus aspirin in patients older than 75 years with atrial fibrillation.

Vessel wall inflammation in spontaneous cervical artery dissection: a prospective, observational positron emission tomography, computed tomography, and magnetic resonance imaging study.

Cannabis use, ischemic stroke, and multifocal intracranial vasoconstriction: a prospective study in 48 consecutive young patients.

Transfer delay is a major factor limiting the use of intra-arterial treatment in acute ischemic stroke.

A new therapeutic strategy for acute ischemic stroke: sequential combined intravenous tPA-tenecteplase for proximal middle cerebral artery occlusion based on first results in 13 consecutive patients.

Heart rate contributes to the vascular effects of chronic mental stress: effects on endothelial function and ischemic brain injury in mice.

Interobserver variability of grading scales for aneurysmal subarachnoid hemorrhage.

Seamless integrated stroke telemedicine systems of care: a potential solution for acute stroke care delivery delays and inefficiencies.

Letter by Murphy et al regarding article, 'Fugl-Meyer assessment of sensorimotor function after stroke: standardized training procedure for clinical practice and clinical trials'.

Does impaired cerebrovascular reactivity predict stroke risk in asymptomatic carotid stenosis? A prospective substudy of the asymptomatic carotid emboli study.

Letter by Makris et al regarding article, 'Carotid artery stenting versus carotid endarterectomy: a comprehensive meta-analysis of short-term and long-term outcomes'.

Letter by Antonopoulos et al regarding article, 'Carotid artery stenting versus carotid endarterectomy: a comprehensive meta-analysis of short-term and long-term outcomes'.

Letter by Huon and Wang regarding article, 'Risk of stroke in patients hospitalized for isolated vertigo: a 4-year follow-up study'.

Frequency of increased blood pressure levels during systemic thrombolysis and risk of intracerebral hemorrhage.

Letter by Doehner et al regarding article, 'Association between obesity and mortality after acute first-ever stroke: the obesity-stroke paradox'.

Letter by Borja and Garcia-Rafanell regarding article, 'Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association'.

Anticoagulation in patients with stroke with infective endocarditis is safe.

Anticoagulation in patients with stroke with infective endocarditis: the sword of Damocles.

Wisdom and determination in the ongoing pursuit of the ever-elusive neuroprotective agent.

Letter by Paraskevas et al regarding article, 'Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/american Stroke Association'.

Anticoagulation should not be used in most patients with stroke with infective endocarditis.

Letter by Naylor regarding article, 'Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association'.

Effects of neural progenitor cells on sensorimotor recovery and endogenous repair mechanisms after photothrombotic stroke.

The ABCs of accurate volumetric measurement of cerebral hematoma.

Partial aortic occlusion for cerebral perfusion augmentation: safety and efficacy of NeuroFlo in Acute Ischemic Stroke trial.

Outcome measurement in stroke: a scale selection strategy.

CT angiographic source images predict outcome and final infarct volume better than noncontrast CT in proximal vascular occlusions.

Year: 2011 Volume: 42 Issue: 5

Year: 2011 Volume: 42 Issue: 4

Year: 2011 Volume: 42 Issue: 3

Year: 2011 Volume: 42 Issue: 2

Year: 2011 Volume: 42 Issue: 1

Year: 2011 Volume: 42 Issue: 1 Supplementary

Year: 2010 Volume: 41

Year: 2009 Volume: 40

Year: 2008 Volume: 39

Year: 2007 Volume: 38

Year: 2006 Volume: 37

Year: 2005 Volume: 36

Year: 2004 Volume: 35

Year: 2003 Volume: 34

Year: 2002 Volume: 33

Year: 2001 Volume: 32

A new therapeutic strategy for acute ischemic stroke: sequential combined intravenous tPA-tenecteplase for proximal middle cerebral artery occlusion based on first results in 13 consecutive patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chausson, Nicolas Joux, Julien Edimonana, Mireille Bartoli, Blaise Aveillan, Mathieu Jeannin, Séverine Signaté, Aïssatou Olindo, Stéphane Smadja, Didier Saint-Vil, Martine Cabre, Philippe
Description	Author Affiliation: Smadja D ( Department of Neurology and Stroke Center, University Hospital of Fort-de-France, BP 632, 97261 Fort-de-France Cedex, Martinique, French West Indies. didier.smadja@chu-fortdefrance.fr)
Abstract	BACKGROUND AND PURPOSE: Intravenous tissue-type plasminogen activator (IV tPA) frequently fails to recanalize proximal middle cerebral artery (MCA-M1) obstructions, preventing favorable outcomes. Only neurointerventional procedures prevail in these cases, but well-equipped centers remain scarce. A new therapeutic strategy consisting of a second IV thrombolysis with low-dose tenecteplase was applied. METHODS: Consecutive patients with an MCA-M1 occlusion that did not reopen at the end of IV tPA perfusion received IV tenecteplase (0.1 mg/kg). Partial or complete thrombolysis in myocardial infarction recanalization (Thrombolysis In Myocardial Infarction grade 2/3) and intracerebral hemorrhage were assessed by magnetic resonance aging approximately 24 hours later. Clinical outcomes at 3 months were evaluated with the modified Rankin score. RESULTS: Among 40 patients with MCA-M1 occlusions who received IV tPA, 13 were treated according to the protocol of sequential combined IV thrombolytics. Baseline National Institutes of Health Stroke Scale score was 15. At a mean of 16.8 hours after IV thrombolysis, the recanalization rate was 100% (2 with Thrombolysis In Myocardial Infarction grade 2, 11 with Thrombolysis In Myocardial Infarction grade 3). Intracerebral hemorrhage occurred in 4 of 13 (31%) patients, with no symptomatic hemorrhage. Good clinical outcomes (modified Rankin score = 0/1) were achieved in 9 of 13 (69%) patients. Functional outcomes were very similar to those of 13 patients with early IV-tPA recanalization. Among 4 patients treated as protocol violations, 1 presented with a lack of recanalization and a parenchymal hematoma type 2. CONCLUSIONS: For patients with MCA-M1 occlusions treated with IV tPA but without early recanalization, a second bolus of IV tenecteplase (0.1 mg/kg) may be a relatively safe, effective, and easy option in carefully selected cases, but additional studies are needed to confirm these findings.
ISSN	00392499
e-ISSN	15244628
Journal	Stroke
Issue Number	6
Volume Number	42
Language	English
Publisher	Lippincott Williams & Wilkins (on behalf of the American Heart Association)
Publisher Date	2011-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Brain Ischemia Drug Therapy Fibrinolytic Agents Therapeutic Use Infarction, Middle Cerebral Artery Stroke Tissue Plasminogen Activator Drug Therapy, Combination Pathology Injections, Intravenous Research Support, Non-u.s. Gov't Discipline Cardiology
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine Neuroscience Advanced and Specialized Nursing Neurology (clinical)

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in