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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chen, Chiao-Chi V. Chin, Li-Te Chu, Chi-Hong Shen, Chiung-Chyi Cho, Der-Yang Ma, Hsin-I Chuang, Hao-Yu Chiu, Cheng-Di Chang, Chen |
| Description | Country affiliation: Taiwan Author Affiliation: Chiu CD ( Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.) |
| Abstract | BACKGROUND AND PURPOSE: Intracerebral hemorrhage (ICH) is associated with high mortality and neurological deficits, and concurrent hyperglycemia usually worsens clinical outcomes. Aquaporin-4 (AQP-4) is important in cerebral water movement. Our aim was to investigate the role of AQP-4 in hyperglycemic ICH. METHODS: Hyperglycemia was induced by intraperitoneal injection of streptozotocin (STZ; 60 mg/kg) in adult Sprague-Dawley male rats. ICH was induced by stereotaxic infusion of collagenase/heparin into the right striatum. One set of rats was repeatedly monitored by MRI at 1, 4, and 7 days after ICH induction so as to acquire information on the formation of hematoma and edema. Another set of rats was killed and brains were examined for differences in the degree of hemorrhage and edema, water content, blood-brain barrier destruction, and AQP-4 expression. RESULTS: Hyperglycemia ICH rats exhibited increased brain water content, more severe blood-brain barrier destruction, and greater vasogenic edema as seen on diffusion-weighted MRI. Significant downregulation of AQP-4 was observed in STZ-treated rats after ICH as compared with non-STZ-treated rats. Apoptosis was greater on day 1 after ICH in STZ-treated rats. CONCLUSIONS: The expression of AQP-4 in the brain is downregulated in hyperglycemic rats as compared with normoglycemic rats after ICH. This change is accompanied by increased vasogenic brain edema and more severe blood-brain barrier destruction. |
| ISSN | 00392499 |
| e-ISSN | 15244628 |
| Journal | Stroke |
| Issue Number | 6 |
| Volume Number | 44 |
| Language | English |
| Publisher | Lippincott Williams & Wilkins (on behalf of the American Heart Association) |
| Publisher Date | 2013-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Aquaporin 4 Physiology Cerebral Hemorrhage Epidemiology Physiopathology Diffusion Magnetic Resonance Imaging Down-regulation Hyperglycemia Animals Genetics Brain Edema Pathology Chemically Induced Collagenases Administration & Dosage Adverse Effects Comorbidity Disease Models, Animal Hematoma Heparin Infusions, Intraventricular Injections, Intraperitoneal Rats, Sprague-dawley Streptozocin Research Support, Non-u.s. Gov't Discipline Cardiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine Neuroscience Advanced and Specialized Nursing Neurology (clinical) |
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