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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Davenport, Matthew D. Barrile, Dana K. Blight, Andrew R. Wu, Rui Caggiano, Anthony O. Huang, Zhihong Parry, Tom J. Ren, Jingmei Finklestein, Seth P. Iaci, Jennifer F. |
| Description | Country affiliation: United States Author Affiliation: Iaci JF ( Acorda Therapeutics, Inc, Ardsley, NY, USA. jiaci@acorda.com) |
| Abstract | BACKGROUND AND PURPOSE: Stroke survivors often have permanent deficits that are only partially addressed by physical therapy. This study evaluated the effects of dalfampridine, a potassium channel blocker, on persistent sensorimotor deficits in rats with treatment initiated 4 or 8 weeks after stroke. METHODS: Rats underwent permanent middle cerebral artery occlusion. Sensorimotor function was measured using limb-placing and body-swing symmetry tests, which normally show a partial recovery from initial deficits that plateaus ≈4 weeks after permanent middle cerebral artery occlusion. Dalfampridine was administered starting at 4 or 8 weeks after permanent middle cerebral artery occlusion in 2 blinded, vehicle-controlled studies. Plasma samples were collected and brain tissue was processed for histologic assessment. RESULTS: Dalfampridine treatment (0.5-2.0 mg/kg) improved forelimb- and hindlimb-placing responses and body-swing symmetry in a reversible and dose-dependent manner. Plasma dalfampridine concentrations correlated with dose. Brain infarct volumes showed no differences between treatment groups. CONCLUSIONS: Dalfampridine improves sensorimotor function in the rat permanent middle cerebral artery occlusion model. Dalfampridine extended-release tablets (prolonged release fampridine outside the United States) are used to improve walking in patients with multiple sclerosis, and these preclinical data provide a strong rationale for examining the potential of dalfampridine to treat chronic stable deficits in stroke patients. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov. Unique identifier: NCT01605825. |
| ISSN | 00392499 |
| e-ISSN | 15244628 |
| Journal | Stroke |
| Issue Number | 7 |
| Volume Number | 44 |
| Language | English |
| Publisher | Lippincott Williams & Wilkins (on behalf of the American Heart Association) |
| Publisher Date | 2013-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | 4-aminopyridine Therapeutic Use Disease Models, Animal Infarction, Middle Cerebral Artery Drug Therapy Potassium Channel Blockers Pharmacology Psychomotor Performance Drug Effects Administration & Dosage Animals Cross-over Studies Dose-response Relationship, Drug Blood Physiopathology Rats, Sprague-dawley Time Factors Randomized Controlled Trial Discipline Cardiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine Neuroscience Advanced and Specialized Nursing Neurology (clinical) |
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