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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hattingen, Elke Wagner, Marlies Singer, Oliver C. Deichmann, Ralf Seiler, Alexander Nöth, Ulrike Bauer, Sonja |
| Description | Country affiliation: Germany Author Affiliation: Bauer S ( From the Department of Neurology (S.B., A.S., O.C.S.), Institute for Neuroradiology (M.W., E.H.)); Wagner M ( From the Department of Neurology (S.B., A.S., O.C.S.), Institute for Neuroradiology (M.W., E.H.)); Seiler A ( From the Department of Neurology (S.B., A.S., O.C.S.), Institute for Neuroradiology (M.W., E.H.)); Hattingen E ( From the Department of Neurology (S.B., A.S., O.C.S.), Institute for Neuroradiology (M.W., E.H.)); Deichmann R ( From the Department of Neurology (S.B., A.S., O.C.S.), Institute for Neuroradiology (M.W., E.H.)); Nöth U ( From the Department of Neurology (S.B., A.S., O.C.S.), Institute for Neuroradiology (M.W., E.H.)); Singer OC ( From the Department of Neurology (S.B., A.S., O.C.S.), Institute for Neuroradiology (M.W., E.H.)) |
| Abstract | BACKGROUND AND PURPOSE: Quantitative T2'-mapping detects regional changes in the relation of oxygenated and deoxygenated haemoglobine and might reflect areas with increased oxygen extraction. T2'-mapping in conjunction with an elaborate algorithm for motion correction was performed in patients with acute large-vessel stroke, and quantitative T2'-values were determined within the diffusion-weighted imaging lesion and perfusion-restricted tissue. METHODS: Eleven patients (median age, 71 years) with acute middle cerebral or internal carotid artery occlusion underwent MRI before scheduled endovascular treatment. MR-examination included diffusion- and perfusion-weighted imaging and quantitative, motion-corrected mapping of T2'. Time-to-peak maps were thresholded for different degrees of perfusion delays (eg, ≥0 s, ≥ 2s) when compared with a reference time-to-peak value from healthy contralateral tissue. Mean T2'-values in areas with reduced apparent diffusion coefficient and in areas with impaired perfusion were compared with T2'-values in corresponding contralateral areas. RESULTS: Median time between symptom onset and MRI was 238 minutes. T2'-values were significantly reduced within the apparent diffusion coefficient -lesion when compared with contralateral healthy tissue (83 ms [67, 97] versus 97 ms [91, 111]; P<0.003). In perfusion-restricted tissue, T2'-values were also significantly lower when compared with contralateral healthy tissue (ie, for time to peak, ≥0 s 93 ms [86, 102] versus 104 [90, 110]; P=0.008) but were significantly higher than within the apparent diffusion coefficient lesion. The severity of the perfusion impairment had no influence on median T2'-values. CONCLUSIONS: Motion-corrected T2'-mapping reveals significant and gradually declining values from healthy to perfusion-disturbed to apparent diffusion coefficient-restricted tissue. Current T2'-mapping can differentiate between the ischemic core and the perfusion-impaired areas but not on its own between penumbral and oligemic tissue. |
| ISSN | 00392499 |
| e-ISSN | 15244628 |
| Journal | Stroke |
| Issue Number | 11 |
| Volume Number | 45 |
| Language | English |
| Publisher | Lippincott Williams & Wilkins (on behalf of the American Heart Association) |
| Publisher Date | 2014-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Brain Ischemia Diagnosis Brain Mapping Diffusion Magnetic Resonance Imaging Echo-planar Imaging Stroke Metabolism Pilot Projects Discipline Cardiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine Neuroscience Advanced and Specialized Nursing Neurology (clinical) |
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