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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Divsalar, Adeleh Saeidifar, Maryam Saboury, Ali Akbar Mansouri-Torshizi, Hassan |
| Description | Country affiliation: Iran Author Affiliation: Mansouri-Torshizi H ( Department of Chemistry, University of Sistan and Baluchestan, Zahedan, Iran. hmtorshizi@hamoon.usb.ac.ir) |
| Abstract | The interaction of calf thymus DNA (CT-DNA) with a novel synthesized and characterized Palladium (II) complex with the formula of [Pd (Et-dtc) (phen)] NO(3) (where phen is 1,10-phenanthroline and Et-dtc is ethyldithiocarbamate) was extensively studied by various spectroscopic techniques. UV-vis studies imply that there is a set of 6 binding sites for the complex on DNA with positive cooperativity in the binding process. This complex unexpectedly denatures the DNA at very low concentration (approximately 9.8 microM). Gel filtration studies indicate that the binding of metal complex with DNA is strong enough not to readily break. Fluorescence studies show that the palladium complex intercalates in DNA through the planar 1,10-phenanthroline ligand presented in its structure. Several binding and thermodynamic parameters are also described. Furthermore, anti-tumor studies of this water soluble complex against human cell tumor lines (K562) have been done. It shows 50% cytotoxic concentration (Ic(50)) value much lower than that of cisplatin. |
| ISSN | 13861425 |
| Issue Number | 1 |
| Volume Number | 77 |
| e-ISSN | 18733557 |
| Journal | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-09-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Antineoplastic Agents Pharmacology Dna Metabolism Palladium Phenanthrolines Thiocarbamates Binding Sites Binding, Competitive Drug Effects Cell Death Cell Proliferation Chromatography Ethidium Humans K562 Cells Magnetic Resonance Spectroscopy Nucleic Acid Denaturation Spectrometry, Fluorescence Thermodynamics Titrimetry Journal Article Research Support, Non-u.s. Gov't Discipline Spectroscopy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Atomic and Molecular Physics, and Optics Analytical Chemistry Instrumentation |
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