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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bakkialakshmi, S. Chandrakala, D. |
| Description | Country affiliation: India Author Affiliation: Bakkialakshmi S ( Department of Physics, Annamalai University, Annamalai nagar, Tamil Nadu, India. bakkialakshmis@rocketmail.com) |
| Abstract | The binding of anticancer drugs (i) Uracil (U), (ii) 5-Fluorouracil (5FU) and (iii) 5-Chlorouracil (5ClU), to bovine serum albumin (BSA) at two levels of temperature was studied by the fluorescence of quenching method. UV/Vis, time-resolved fluorescence, Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance ((1)H NMR) and scanning electron microscope (SEM) analyses were also made. Binding constants (K(a)) and binding sites (n) at various levels of temperature were calculated. The obtained binding sites were found to be equal to one for all the three quenchers (U, 5FU and 5ClU) at two different temperature levels. Thermodynamic parameters ΔH, ΔG and ΔS have been calculated and were presented in tables. Change in FTIR absorption intensity shows strong binding of anticancer drugs to BSA. Changes in chemical shifts of NMR and fluorescence lifetimes of the drugs indicate the presence of interaction and binding of BSA to anticancer drugs. (1)H NMR spectra and SEM photographs also conform this binding. |
| ISSN | 13861425 |
| Volume Number | 88 |
| e-ISSN | 18733557 |
| Journal | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Antineoplastic Agents Metabolism Serum Albumin, Bovine Animals Analysis Chemistry Binding Sites Cattle Fluorouracil Kinetics Magnetic Resonance Spectroscopy Protein Binding Ultrastructure Spectrophotometry, Ultraviolet Spectroscopy, Fourier Transform Infrared Temperature Time Factors Uracil Analogs & Derivatives Journal Article Research Support, Non-u.s. Gov't Discipline Spectroscopy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Atomic and Molecular Physics, and Optics Analytical Chemistry Instrumentation |
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