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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Xiong, Daxing Zeng, Birong Zhang, Jun Chen, Lingnan Kang, Qilong |
| Description | Country affiliation: China Author Affiliation: Zhang J ( Department of Physics, School of Physics and Information Engineering, Fuzhou University, Fuzhou 350108, China.) |
| Abstract | The interaction between pyrrolizine derivatives (PD) and bovine serum albumin (BSA) under imitated physiological conditions was analyzed by fluorescence and ultraviolet spectra. The experiments were conducted at three different temperatures (302, 306 and 310 K) and the results showed that PD caused the fluorescence quenching of BSA through a combined quenching procedure. The binding constant (K(a)), binding-site number (n) between PD and BSA at different temperatures were obtained. According to Förster non-radiation energy transfer theory, the binding distance (r) between BSA and PD was calculated. The corresponding thermodynamic parameters (ΔG, ΔH, and ΔS) were also obtained. The comparison of binding potency of PD and BSA suggested that the substituent on the benzene ring could enhance the binding affinity of PD and BSA. Finally, we investigated the possible sub-domain on BSA where bind PD by displacement experiments. |
| ISSN | 13861425 |
| Volume Number | 96 |
| e-ISSN | 18733557 |
| Journal | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Pyrrolizidine Alkaloids Metabolism Serum Albumin, Bovine Absorption Animals Binding Sites Cattle Energy Transfer Kinetics Ligands Protein Binding Chemistry Spectrometry, Fluorescence Spectrophotometry, Ultraviolet Temperature Journal Article Research Support, Non-u.s. Gov't Discipline Spectroscopy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Atomic and Molecular Physics, and Optics Analytical Chemistry Instrumentation |
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