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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Neelakantan, M. A. Thalamuthu, S. Annaraj, B. Jeslin Kanaga Inba, P. |
| Description | Country affiliation: India Author Affiliation: Jeslin Kanaga Inba P ( Chemistry Research Centre, National Engineering College, KR Nagar, Kovilpatti 628 503, Thoothukudi District, Tamil Nadu, India.) |
| Abstract | Salen [2,2'-{propane-1,3-diylbis[nitrilo(E)methylylidene]}bis(6-methoxyphenol)], reduced salen [(2,2'-[propane-1,3-diylbis(iminomethylene))]bis(6-methoxyphenol)] and N-alkylated salen [diethyl-2,2'-(propane-1,3-diylbis((2-hydroxy-3-methoxybenzyl) azanediyl))diacetate] compounds have been synthesized and characterized by IR, (1)H NMR, (13)C NMR and UV-vis. spectroscopy. Molecular geometry of the title compounds in the ground state has been optimized by density functional method (B3LYP) with 6-31 G basis set. Vibrational frequencies of the compounds were computed and compared with the experimental values. Tautomeric stability study of salen inferred that the enolimine form is more stable than its ketoenamine form in gas phase. The spectral behavior of salen in polar and nonpolar solvents was examined demonstrate the positive solvatochromism. The synthesized compounds have been studied with respect to their binding to calf thymus DNA showed that there were interactions between the compounds and DNA through a groove binding mode. Furthermore, the DNA cleavage activity of the compounds has been investigated by gel electrophoresis. The antioxidant properties of compounds were evaluated by DPPH method. The N-alkylated compound has a higher DPPH free radical scavenging activity. The antimicrobial activity was investigated on various gram positive and gram negative bacteria. |
| ISSN | 13861425 |
| Volume Number | 104 |
| e-ISSN | 18733557 |
| Journal | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Ethylenediamines Chemical Synthesis Pharmacology Absorption Alkylation Animals Anti-infective Agents Bacteria Drug Effects Biphenyl Compounds Chemistry Cattle Dna Metabolism Deoxyribonucleases Electrons Hydrogen-ion Concentration Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Models, Molecular Molecular Conformation Oxidation-reduction Picrates Quantum Theory Solutions Solvents Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Thermodynamics Vibration Journal Article Research Support, Non-u.s. Gov't Discipline Spectroscopy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Atomic and Molecular Physics, and Optics Analytical Chemistry Instrumentation |
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