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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Singaravelu, G. Govindaraju, K. Mohamed Sadiq, A. Tamilselvan, S. Venkatachalam, M. Ganesh Kumar, V. |
| Description | Country affiliation: India Author Affiliation: Venkatachalam M ( Department of Biochemistry, Institute of Veterinary Preventive Medicine, Ranipet 632402, India.) |
| Abstract | In the present investigation, functionalization of gold nanoparticles synthesized using propanoic acid 2-(3-acetoxy-4,4,14-trimethylandrost-8-en-17-yl) (PAT) an active biocomponent isolated from Cassia auriculata is studied in detail. On reaction of PAT with aqueous HAuCl4, rapid formation of stable gold nanoparticles was achieved. Formation of gold nanoparticles was confirmed by UV-vis spectroscopy, XRD, GC-MS,FTIR, TEM and SEM with EDAX. Gold nanoparticles mostly were monodisperse, spherical in shape and ranged in size 12-41 nm. Gold nanoparticles synthesised using PAT was administered to alloxan (150 mg/kg body weight) induced diabetic male albino rats at different doses (0.25, 0.5, 0.75 and 1.0mg/kg body weight) for 28 days. Plasma glucose level, cholesterol and triglyceride were significantly (p<0.001) reduced in experimental animals treated with gold nanoparticles at dosage of 0.5mg/kg body weight and plasma insulin increased significantly. The newly genre green gold nanoparticles exhibit remarkable protein tyrosine phosphatase 1B inhibitory activity. |
| ISSN | 13861425 |
| Volume Number | 116 |
| e-ISSN | 18733557 |
| Journal | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Cassia Chemistry Diabetes Mellitus, Experimental Drug Therapy Gold Therapeutic Use Hypoglycemic Agents Nanoparticles Plant Extracts Animals Blood Glucose Analysis Body Weight Drug Effects Chlorides Blood Enzymology Metabolism Gold Compounds Green Chemistry Technology Male Ultrastructure Protein Tyrosine Phosphatase, Non-receptor Type 1 Antagonists & Inhibitors Rats Journal Article Discipline Spectroscopy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Atomic and Molecular Physics, and Optics Analytical Chemistry Instrumentation |
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