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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gevriya, Bhavesh Thakkar, Disha Mashru, R. C. |
| Description | Author Affiliation: Thakkar D ( Quality Assurance Laboratory, Centre of Relevance and Excellence in Novel Drug Delivery System, Pharmacy Department, The Maharaja Sayajirao University of Baroda, G.H. Patel Building, Donor's Plaza, Fatehgunj, Vadodara 390 002, Gujarat, India. Electronic address: dishathakkar282@gmail.com.); Gevriya B ( Quality Assurance Laboratory, Centre of Relevance and Excellence in Novel Drug Delivery System, Pharmacy Department, The Maharaja Sayajirao University of Baroda, G.H. Patel Building, Donor's Plaza, Fatehgunj, Vadodara 390 002, Gujarat, India.); Mashru RC ( Quality Assurance Laboratory, Centre of Relevance and Excellence in Novel Drug Delivery System, Pharmacy Department, The Maharaja Sayajirao University of Baroda, G.H. Patel Building, Donor's Plaza, Fatehgunj, Vadodara 390 002, Gujarat, India. Electronic address: rajshreemashru@yahoo.com.) |
| Abstract | Linezolid reacted with palladium to form 1:1 binary cationic chelate which further reacted with eosin dye to form 1:1 ternary ion association complex at pH 4 of Walpole's acetate buffer in the presence of methyl cellulose. As a result not only absorption spectra were changed but Resonance Rayleigh Scattering (RRS), Second-order Scattering (SOS) and Frequency Doubling Scattering (FDS) intensities were greatly enhanced. The analytical wavelengths of RRS, SOS and FDS (λex/λem) of ternary complex were located at 538 nm/538nm, 240 nm/480 nm and 660 nm/330 nm, respectively. The linearity range for RRS, SOS and FDS methods were 0.01-0.5 µg mL(-1), 0.1-2 µg mL(-1) and 0.2-1.8 µg mL(-1), respectively. The sensitivity order of three methods was as RRS>SOS>FDS. Accuracy of all methods were determined by recovery studies and showed recovery between 98% and 102%. Intraday and inter day precision were checked for all methods and %RSD was found to be less than 2 for all methods. The effects of foreign substances were tested on RRS method and it showed the method had good selectivity. For optimization of process parameter, Taguchi orthogonal array design L8(2(4)) was used and ANOVA was adopted to determine the statistically significant control factors that affect the scattering intensities of methods. The reaction mechanism, composition of ternary ion association complex and reasons for scattering intensity enhancement was discussed in this work. |
| ISSN | 13861425 |
| Volume Number | 122 |
| e-ISSN | 18733557 |
| Journal | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-03-25 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Acetamides Chemistry Chelating Agents Light Models, Molecular Oxazolidinones Palladium Scattering, Radiation Blood Analysis Of Variance Eosine Yellowish-(ys) Humans Linezolid Reference Standards Reproducibility Of Results Signal-to-noise Ratio Spectrum Analysis Tablets Journal Article Discipline Spectroscopy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Atomic and Molecular Physics, and Optics Analytical Chemistry Instrumentation |
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