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Modelling, verification, and calibration of a photoacoustics based continuous non-invasive blood glucose monitoring system.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sarangi, Satyabrata Banerjee, Swapna Pai, Praful P. Sanki, Pradyut K.
Description	Country affiliation: India Author Affiliation: Pai PP ( Department of Electronics and Electrical Communication Engineering, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India.); Sanki PK ( Department of Electronics and Electrical Communication Engineering, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India.); Sarangi S ( Department of Electronics and Electrical Communication Engineering, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India.); Banerjee S ( Department of Electronics and Electrical Communication Engineering, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India.)
Abstract	This paper examines the use of photoacoustic spectroscopy (PAS) at an excitation wavelength of 905 nm for making continuous non-invasive blood glucose measurements. The theoretical background of the measurement technique is verified through simulation. An apparatus is fabricated for performing photoacoustic measurements in vitro on glucose solutions and in vivo on human subjects. The amplitude of the photoacoustic signals measured from glucose solutions is observed to increase with the solution concentration, while photoacoustic amplitude obtained from in vivo measurements follows the blood glucose concentration of the subjects, indicating a direct proportionality between the two quantities. A linear calibration method is applied separately on measurements obtained from each individual in order to estimate the blood glucose concentration. The estimated glucose values are compared to reference glucose concentrations measured using a standard glucose meter. A plot of 196 measurement pairs taken over 30 normal subjects on a Clarke error grid gives a point distribution of 82.65% and 17.35% over zones A and B of the grid with a mean absolute relative deviation (MARD) of 11.78% and a mean absolute difference (MAD) of 15.27 mg/dl (0.85 mmol/l). The results obtained are better than or comparable to those obtained using photoacoustic spectroscopy based methods or other non-invasive measurement techniques available. The accuracy levels obtained are also comparable to commercially available continuous glucose monitoring systems.
ISSN	00346748
Issue Number	6
Volume Number	86
e-ISSN	10897623
Journal	Review of Scientific Instruments
Language	English
Publisher	American Institute of Physics
Publisher Date	2015-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Blood Chemical Analysis Instrumentation Blood Glucose Diagnostic Techniques, Endocrine Monitoring, Physiologic Photoacoustic Techniques Spectrum Analysis Methods Calibration Computer Simulation Humans Models, Theoretical Journal Article Research Support, Non-u.s. Gov't Validation Studies Discipline Physics Discipline Chemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Instrumentation

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