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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Morita, E. H. Shirakawa, M. Imagawa, M. Hayashi, F. Kyogoku, Y. |
| Description | Country affiliation: Japan Author Affiliation: Morita EH ( Institute for Protein Research, Osaka University, Japan.) |
| Abstract | The POU-homeodomain (POUH) forms the bipartite DNA-binding POU domain in association with the POU-specific domain. The 1H, 15N, and 13C magnetic resonances of the 67-amino acid long POUH of mouse Oct-3 have almost completely been assigned, mainly through the combined use of three-dimensional triple resonance NMR methods. Based on the distance and dihedral angle constraints derived from the NMR data, the solution structure of the POUH domain has been calculated by the ab initio simulated annealing method. The average RMS deviation for all backbone heavy atoms of the 20 best calculated structures for residues 9-53 of the total 67 amino acid residues is 0.44 A. The POUH domain consists of three alpha-helices (helix-I, 10-20; helix-II, 28-38; and helix-III, 42-53), and helices-II and -III form a helix-turn-helix motif. In comparison with other classical homeodomains, the folding of the three helices is quite similar. However, the length of helix-III is fairly short. In the complex of the Oct-1 POU domain with an octamer site (Klemm JD, et al., 1994, Cell 77:21-32), the corresponding region is involved in helix-III. The structural difference between these two cases will be discussed. |
| ISSN | 09618368 |
| e-ISSN | 1469896X |
| Journal | Protein Science |
| Issue Number | 4 |
| Volume Number | 4 |
| Language | English |
| Publisher | Wiley-Blackwell (on behalf of The Protein Society) |
| Publisher Date | 1995-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Dna-binding Proteins Chemistry Homeodomain Proteins Transcription Factors Amino Acid Sequence Animals Magnetic Resonance Spectroscopy Mice Models, Molecular Molecular Sequence Data Octamer Transcription Factor-3 Pou Domain Factors Protein Conformation Protein Structure, Secondary Research Support, Non-u.s. Gov't Discipline Biochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Molecular Biology Biochemistry |
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