NDLI: Entropy-enthalpy compensation: fact or artifact?

Please wait, while we are loading the content...

Year: 2017 Volume: 26

Year: 2016 Volume: 25

Year: 2015 Volume: 24

Year: 2014 Volume: 23

Year: 2013 Volume: 22

Year: 2012 Volume: 21

Year: 2011 Volume: 20

Year: 2010 Volume: 19

Year: 2009 Volume: 18

Year: 2008 Volume: 17

Year: 2007 Volume: 16

Year: 2006 Volume: 15

Year: 2005 Volume: 14

Year: 2004 Volume: 13

Year: 2003 Volume: 12

Year: 2002 Volume: 11

Year: 2001 Volume: 10

Year: 2001 Volume: 10 Issue: 12

Year: 2001 Volume: 10 Issue: 11

Year: 2001 Volume: 10 Issue: 10

Year: 2001 Volume: 10 Issue: 9

Year: 2001 Volume: 10 Issue: 8

Year: 2001 Volume: 10 Issue: 7

Year: 2001 Volume: 10 Issue: 6

Year: 2001 Volume: 10 Issue: 5

Year: 2001 Volume: 10 Issue: 4

Year: 2001 Volume: 10 Issue: 3

Effect of the N1 residue on the stability of the α-helix for all 20 amino acids

Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach.

Conformational analysis of putative regulatory subunit D of the toluene/o-xylene-monooxygenase complex from Pseudomonas stutzeri OX1

Reduced antibody response to streptavidin through site-directed mutagenesis.

HMG-D complexed to a bulge DNA: an NMR model.

In vivo assembly of aspartate transcarbamoylase from fragmented and circularly permuted catalytic polypeptide chains.

Random circular permutation leading to chain disruption within and near alpha helices in the catalytic chains of aspartate transcarbamoylase: effects on assembly, stability, and function.

Solution structure and backbone dynamics of an ω-conotoxin precursor

Characterization of the N-terminal repeat domain of Escherichia coli ClpA-A class I Clp/HSP100 ATPase.

Identification of intrinsic order and disorder in the DNA repair protein XPA.

Physicochemical consequences of the perdeuteriation of glutathione S-transferase from S. japonicum.

A general method for the quantitative analysis of functional chimeras: Applications from site-directed mutagenesis and macromolecular association

Solution structure of the DNA-binding domain of the TyrR protein of Haemophilus influenzae.

CODA: a combined algorithm for predicting the structurally variable regions of protein models.

Leucine 41 is a gate for water entry in the reduction of Clostridium pasteurianum rubredoxin.

Single amino acid substitutions on the surface of Escherichia coli maltose-binding protein can have a profound impact on the solubility of fusion proteins.

Effects of charged amino acids at b and c heptad positions on specificity and stability of four-chain coiled coils.

Crystal structure of threonine synthase from Arabidopsis thaliana.

Designed heterodimerizing leucine zippers with a ranger of pIs and stabilities up to 10(-15) M.

Unusual evolutionary history of the tRNA splicing endonuclease EndA: relationship to the LAGLIDADG and PD-(D/E)XK deoxyribonucleases.

Entropy-enthalpy compensation: fact or artifact?

Open-and-shut cases in coiled-coil assembly: alpha-sheets and alpha-cylinders.

Year: 2001 Volume: 10 Issue: 2

Year: 2001 Volume: 10 Issue: 1

Year: 2000 Volume: 9

Year: 1999 Volume: 8

Year: 1998 Volume: 7

Year: 1997 Volume: 6

Year: 1996 Volume: 5

Year: 1995 Volume: 4

Year: 1994 Volume: 3

Year: 1993 Volume: 2

Year: 1992 Volume: 1

Entropy-enthalpy compensation: fact or artifact?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sharp, K.
Description	Country affiliation: United States Author Affiliation: Sharp K ( Johnson Research Foundation, Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA. sharpk@mail.med.upenn.edu)
Abstract	The phenomenon of entropy-enthalpy (S-H) compensation is widely invoked as an explanatory principle in thermodynamic analyses of proteins, ligands, and nucleic acids. It has been suggested that this compensation is an intrinsic property of either complex, fluctuating, or aqueous systems. The questions examined here are whether the observed compensation is extra-thermodynamic (i.e., reflects anything more than the well-known laws of statistical thermodynamics) and if so, what does it reveal about the system? Compensation is rather variably defined in the literature and different usages are discussed. The most precise and interesting one, which is considered here, is a linear relationship between DeltaH and DeltaS for some series of perturbations or changes in experimental variable. Some recent thermodynamic data on proteins purporting to show compensation is analyzed and shown to be better explained by other causes. A general statistical mechanical model of a complex system is analyzed to explore whether and under what conditions extra-thermodynamic compensation can occur and what it reveals about the system. This model shows that the most likely behavior to be seen is linear S-H compensation over a rather limited range of perturbations with a compensation temperature Tc = dDeltaH/dDeltaS within 20% of the experimental temperature. This behavior is insensitive to the details of the model, thus revealing little extra-thermodynamic or causal information about the system. In addition, it will likely be difficult to distinguish this from more trivial forms of compensation in real experimental systems.
ISSN	09618368
e-ISSN	1469896X
Journal	Protein Science
Issue Number	3
Volume Number	10
Language	English
Publisher	Wiley-Blackwell (on behalf of The Protein Society)
Publisher Date	2001-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Entropy Proteins Chemistry Thermodynamics Artifacts Calcium-binding Proteins Chemical Phenomena Chemistry, Physical Cytochrome c Group Models, Chemical Protein Folding Research Support, U.s. Gov't, Non-p.h.s. Research Support, U.s. Gov't, P.h.s. Discipline Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Molecular Biology Biochemistry

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in