NDLI: A model of the replication fork blocking protein Fob1p based on the catalytic core domain of retroviral integrases.

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A model of the replication fork blocking protein Fob1p based on the catalytic core domain of retroviral integrases.

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A model of the replication fork blocking protein Fob1p based on the catalytic core domain of retroviral integrases.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dlakic, Mensur
Description	Country affiliation: United States Author Affiliation: Dlakic M ( Department of Biological Chemistry, The University of Michigan Medical School, Ann Arbor, MI 48109-0606, USA. mensur@umich.edu)
Abstract	The replication fork blocks are common in both prokaryotes and eukaryotes. In most cases, these blocks are associated with increased levels of mitotic recombination. One of the best-characterized replication fork blocks in eukaryotes is found in ribosomal DNA (rDNA) repeats of Saccharomyces cerevisiae. It has been shown that the replication fork blocking protein Fob1p regulates the recombination rate and the number of rDNA copies in S. cerevisiae, but the mechanistic aspects of these events are still poorly understood. Sequence profile searches revealed that Fob1p is related to retroviral integrases. Subsequently, the catalytic domain of HIV-1 integrase was used as a template to build a reliable three-dimensional model of Fob1p. Structural insights from this study may be useful in explaining Fob1p-mediated formation of extrachromosomal rDNA circles that accelerate aging in yeast and recombination events that lead to expansion or contraction of rDNA.
ISSN	09618368
e-ISSN	1469896X
Journal	Protein Science
Issue Number	5
Volume Number	11
Language	English
Publisher	Wiley-Blackwell (on behalf of The Protein Society)
Publisher Date	2002-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Catalytic Domain Dna-binding Proteins Fungal Proteins Chemistry Models, Molecular Saccharomyces Cerevisiae Proteins Amino Acid Sequence Hiv Integrase Molecular Sequence Data Saccharomyces Cerevisiae Sequence Alignment Sequence Analysis, Protein Research Support, Non-u.s. Gov't Discipline Biochemistry
Content Type	Text
Resource Type	Article
Subject	Medicine Molecular Biology Biochemistry

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