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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bastos-Aristizabal, Sara Kozlov, Guennadi Gehring, Kalle |
| Description | Country affiliation: Canada Author Affiliation: Bastos-Aristizabal S ( Department of Biochemistry, Groupe de recherche axé sur la structure des protéines, McGill University, 3649 Promenade Sir William Osler, Montréal, Québec, H3G 0B1, Canada.) |
| Abstract | Protein disulfide isomerases (PDIs) are responsible for catalyzing the proper oxidation and isomerization of disulfide bonds of newly synthesized proteins in the endoplasmic reticulum (ER). Here, it is shown that human PDI (PDIA1) dimerizes in vivo and proposed that the dimerization of PDI has physiological relevance by autoregulating its activity. The crystal structure of the dimeric form of noncatalytic bb' domains of human PDIA1 determined to 2.3 Å resolution revealed that the formation of dimers occludes the substrate binding site and may function as a mechanism to regulate PDI activity in the ER. |
| ISSN | 09618368 |
| e-ISSN | 1469896X |
| DOI | 10.1002/pro.2444 |
| Journal | Protein Science |
| Issue Number | 5 |
| Volume Number | 23 |
| Language | English |
| Publisher | Wiley-Blackwell (on behalf of The Protein Society) |
| Publisher Date | 2014-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Procollagen-proline Dioxygenase Chemistry Protein Disulfide-isomerases Protein Multimerization Binding Sites Crystallography, X-ray Endoplasmic Reticulum Metabolism Models, Molecular Protein Structure, Tertiary Thioredoxins Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s. Discipline Biochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Molecular Biology Biochemistry |
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