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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wodzinski, M. A. Snowden, J. A. Reilly, J. T. |
| Description | Country affiliation: United kingdom Author Affiliation: Wodzinski MA ( Department of Haematology, Northern General Hospital, Sheffield, UK.) |
| Abstract | A 43 year old woman in remission from acute myeloid leukaemia developed abdominal pain, severe melaena, diarrhoea and gram-negative septicaemia whilst severely pancytopenic following consolidation chemotherapy. Subsequently, serial abdominal X-rays showed a progressive toxic megacolon. Conservative management was attempted but, because of radiological evidence of increasing colonic dilatation and incipient perforation, an emergency defunctioning colostomy was performed. The patient recovered and 2 months later the caecostomy was reversed and a right hemicolectomy performed. This first described case of toxic megacolon following leukaemia treatment is compared with three previously described cases following cytotoxic chemotherapy for other conditions. |
| ISSN | 14690756 |
| e-ISSN | 00325473 |
| Journal | Postgraduate Medical Journal |
| Issue Number | 830 |
| Volume Number | 70 |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. (on behalf of the Fellowship of Postgraduate Medicine) |
| Publisher Date | 1994-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Antineoplastic Combined Chemotherapy Protocols Adverse Effects Leukemia, Myeloid, Acute Drug Therapy Megacolon, Toxic Chemically Induced Amsacrine Administration & Dosage Cytarabine Daunorubicin Etoposide Complications Discipline Medicine |
| Content Type | Text |
| Resource Type | Article Case study |
| Subject | Medicine |
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