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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Feeley, K. M. Bhutta, A. S. Kanduru, C. O'Connor, H. J. Cunnane, K. Meehan, J. M. |
| Description | Author Affiliation: O'Connor HJ ( Department of Medicine, General Hospital, Tullamore, Co Offaly, Eire.) |
| Abstract | In a prospective study designed to assess the effect of Helicobacter pylori eradication on peptic ulcer healing, 85 consecutive patients with H. pylori-positive peptic ulcer disease were treated with a triple therapy regimen consisting of colloidal bismuth subcitrate 120 mg four times daily for 28 days, with metronidazole 400 mg three times daily and tetracycline 500 mg three times daily for the first seven days of treatment. H. pylori status was assessed by CLO test and histology at least four weeks after completing therapy. Of 75 patients (88%) H. pylori-negative after therapy, 69 (92%) had healed ulcers compared with only five of 10 patients (50%) who remained H. pylori-positive (p = 0.003). Cigarette smoking had no significant effect on ulcer healing. Our results suggest that H. pylori eradication may accelerate ulcer healing and provide further evidence that an effective helicobactericidal regimen is the treatment of choice in H. pylori-positive peptic ulcer. |
| ISSN | 14690756 |
| e-ISSN | 00325473 |
| Journal | Postgraduate Medical Journal |
| Issue Number | 832 |
| Volume Number | 71 |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. (on behalf of the Fellowship of Postgraduate Medicine) |
| Publisher Date | 1995-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Helicobacter Infections Drug Therapy Helicobacter Pylori Drug Effects Peptic Ulcer Therapy Drug Therapy, Combination Duodenal Ulcer Microbiology Metronidazole Therapeutic Use Organometallic Compounds Prospective Studies Smoking Stomach Ulcer Tetracycline Comparative Study Discipline Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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