NDLI: Tiam1, overexpressed in most malignancies, is a novel tumor biomarker.

Please wait, while we are loading the content...

Ovarian dysgenesis associated with an unbalanced X;6 translocation: first characterisation of reproductive anatomy and cytogenetic evaluation in partial trisomy 6 with breakpoints at Xq22 and 6p23.

An autophagy inhibitor enhances the inhibition of cell proliferation induced by a proteasome inhibitor in MCF-7 cells.

microRNA-18a, a member of the oncogenic miR-17-92 cluster, targets Dicer and suppresses cell proliferation in bladder cancer T24 cells.

Effects of increased matrix metalloproteinase-9 expression on skeletal muscle fibrosis in prolonged alcoholic myopathies of rats.

p300 mediates cellular resistance to doxorubicin in bladder cancer.

Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet.

Obtain osteoarthritis related molecular signature genes through regulation network.

Osteoporosis increases chondrocyte proliferation without a change in apoptosis during fracture healing in an ovariectomized rat model.

Infrasound increases intracellular calcium concentration and induces apoptosis in hippocampi of adult rats.

The sonic hedgehog pathway as a treatment target for extrahepatic biliary tract cancer.

Biochanin A ameliorates the cytokine secretion profile of lipopolysaccharide-stimulated macrophages by a PPARÎ³-dependent pathway.

Down-regulation of Smad4 enhances proliferation and invasion of colorectal carcinoma HCT116 cells and up-regulates Id2.

Inhibition of colon tumor growth by IL-15 immunogene therapy.

Unique CYP3A4 genetic variant in Brazilian tuberculosis patients with/without HIV.

Development of a novel quantitative real-time assay using duplex mutation primers for rapid detection of Candida species.

Hypoxia-induced increases in A549/CDDP cell drug resistance are reversed by RNA interference of HIF-1 expression.

Anti-proliferative effects of cucurmosin on human hepatoma HepG2 cells.

Yessotoxin induces apoptosis in HL7702 human liver cells.

The Akt/FoxO1/p27 pathway mediates the proliferative action of liraglutide in ß cells.

Anti-proliferative effects of Chinese herb Cornus officinalis in a cell culture model for estrogen receptor-positive clinical breast cancer.

Association between promoter polymorphisms of the LIFR gene and schizophrenia with persecutory delusion in a Korean population.

Quantitative promoter hypermethylation analysis of RASSF1A in lung cancer: comparison with methylation-specific PCR technique and clinical significance.

Phosphorylated T567 ezrin is associated with merlin expression in KIT-mutant gastrointestinal stromal tumors.

Dendritic cells transfected with lentiviral vector-encoding hTERT peptide augment antitumor T cell response in vitro.

Differentiation potential of human mesenchymal stem cells derived from adipose tissue and bone marrow to sinus node-like cells.

Tiam1, overexpressed in most malignancies, is a novel tumor biomarker.

Establishment and characterization of human non-small cell lung cancer cell lines.

Immune and inflammatory gene signature in rat cerebrum in subarachnoid hemorrhage with microarray analysis.

Up-regulation of TGF-ß via the activation of extracellular signal-regulated kinase 1 and 2 induced by prorenin in human renal mesangial cells.

SNP rs2470152 in CYP19 is correlated to aromatase activity in Chinese polycystic ovary syndrome patients.

Patients with progressive pseudorheumatoid dysplasia: from clinical diagnosis to molecular studies.

Effect of 5-Aza-2'-deoxycytidine on SLC22A18 in glioma U251 cells.

hsa-miR-96 up-regulates MAP4K1 and IRS1 and may function as a promising diagnostic marker in human bladder urothelial carcinomas.

Effect of membrane toxin 12 isolated from Naja naja atra on proliferation and invasion of human bladder cancer EJ cells.

Interaction between ROS and p38MAPK contributes to chemical hypoxia-induced injuries in PC12 cells.

Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells.

Effects of kallikrein-related peptidase 14 gene inhibition by small interfering RNA in ovarian carcinoma cells.

High myopia is not associated with single nucleotide polymorphisms in the COL2A1 gene in the Chinese population.

Adefovir dipivoxil modulates cytokine expression in Th1/Th2 cells in patients with chronic hepatitis B.

Genes differentially expressed in the peripheral zone compared to the transitional zone of the normal human prostate and their potential regulation by ETS factors.

Risk of cardiovascular disease in kidney donors as a chronic kidney disease cohort.

Computational pharmaceutical analysis of anti-Alzheimer's Chinese medicine Coptidis Rhizoma alkaloids.

Tanshinone IIA inhibits human hepatocellular carcinoma J5 cell growth by increasing Bax and caspase 3 and decreasing CD31 expression in vivo.

Gene expression profiling of high altitude polycythemia in Han Chinese migrating to the Qinghai-Tibetan plateau.

Decidual infiltration of FoxP3â º regulatory T cells, CD3â º T cells, CD56â º decidual natural killer cells and Ki-67 trophoblast cells in hydatidiform mole compared to normal and ectopic pregnancies.

Year: 2011 Volume: 4

Year: 2010 Volume: 3

Year: 2008 Volume: 1

Tiam1, overexpressed in most malignancies, is a novel tumor biomarker.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Guan, Jian Zhang, Gong Zhang, Xiangmei Chen, Bin Ye, Xianghua Ding, Yi Liu, Feiye Liang, Zhao Huang, Jing Luo, Rongcheng Ruan, Jian Wang, Shuang Chen, Longhua
Description	Author Affiliation: Chen B ( General Hospital of Guangzhou Military Command of PLA, Guangzhou, Guangdong 510515, PR China.)
Abstract	T lymphoma invasion and metastasis 1 (Tiam1) is a guanine nucleotide exchange factor (GNEF) family member, and is considered to be involved in many important cellular processes and oncogenesis. In this study, we investigated Tiam1 expression differences between normal tissue and malignant tissue using tissue microarray (TMA), and further studied the Tiam1 mRNA and protein level in 9 hepatoma lines. Forty-nine tumor tissue and 47 normal tissue samples were detected via TMA by immunohistochemistry with polyclonal antibody. Tiam1 expression in 9 human hepatoma cell lines, namely Huh-7, HepG2, Hep3B, SMMC-7721, QGy-7701, QGy-7703, BEL-7402, BEL-7404 and BEL-7405, and 1 normal primary human hepatocyte, HL-7702, was compared by means of fluorescence quantitative PCR, immunocytochemistry assay and Western blotting. We found that Tiam1 was significantly expressed in various malignancies. Tiam1 mRNA and protein levels were significantly elevated in the 9 human hepatoma cell lines compared to the normal primary human hepatocyte. Our results suggest that Tiam1 overexpression in malignant neoplasms could be a novel effective supplementary biomarker for tumors, including hepatocellular carcinoma.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	1
Volume Number	5
Language	English
Publisher	Spandidos Publications
Publisher Date	2012-01-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Tumor Markers, Biological Metabolism Gene Expression Regulation, Neoplastic Guanine Nucleotide Exchange Factors Genetics Carcinoma, Hepatocellular Diagnosis Cell Line Immunohistochemistry Liver Neoplasms Microarray Analysis Rna, Messenger Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Molecular classification and novel targets in hepatocellular carcinoma: recent advancements.

C9orf100, a new member of the Dbl-family guanine nucleotide exchange factors, promotes cell proliferation and migration in hepatocellular carcinoma.

Quantitative evaluation of aldo-keto reductase expression in hepatocellular carcinoma (HCC) cell lines.

Nucleolin identified by comparative massspectra analysis is a potential marker for invasive progression of hepatocellular carcinoma.

A novel biomarker Linc00974 interacting with KRT19 promotes proliferation and metastasis in hepatocellular carcinoma.

Expression and significance of PTEN and miR-92 in hepatocellular carcinoma.

Downregulation of Tcell lymphoma invasion and metastasisinducing factor 1 induces cytoskeletal rearrangement and inhibits the invasive capacity of gastric cancer cells.

Liver cancer: A model of fibrolamellar carcinoma.

Increased expression of OCT4 is associated with low differentiation and tumor recurrence in human hepatocellular carcinoma.

Tiam1, overexpressed in most malignancies, is a novel tumor biomarker.

Similar Documents

Molecular classification and novel targets in hepatocellular carcinoma: recent advancements.

C9orf100, a new member of the Dbl-family guanine nucleotide exchange factors, promotes cell proliferation and migration in hepatocellular carcinoma.

Quantitative evaluation of aldo-keto reductase expression in hepatocellular carcinoma (HCC) cell lines.

Nucleolin identified by comparative mass­spectra analysis is a potential marker for invasive progression of hepatocellular carcinoma.

A novel biomarker Linc00974 interacting with KRT19 promotes proliferation and metastasis in hepatocellular carcinoma.

Expression and significance of PTEN and miR-92 in hepatocellular carcinoma.

Downregulation of T­cell lymphoma invasion and metastasis­inducing factor 1 induces cytoskeletal rearrangement and inhibits the invasive capacity of gastric cancer cells.

Liver cancer: A model of fibrolamellar carcinoma.

Increased expression of OCT4 is associated with low differentiation and tumor recurrence in human hepatocellular carcinoma.

Tiam1, overexpressed in most malignancies, is a novel tumor biomarker.

Nucleolin identified by comparative massspectra analysis is a potential marker for invasive progression of hepatocellular carcinoma.

Downregulation of Tcell lymphoma invasion and metastasisinducing factor 1 induces cytoskeletal rearrangement and inhibits the invasive capacity of gastric cancer cells.