NDLI: Genetically modified Schwann cells producing glial cell line-derived neurotrophic factor inhibit neuronal apoptosis in rat spinal cord injury.

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Genetically modified Schwann cells producing glial cell line-derived neurotrophic factor inhibit neuronal apoptosis in rat spinal cord injury.

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Year: 2014 Volume: 9 Issue: 3

Year: 2014 Volume: 9 Issue: 2

Year: 2014 Volume: 9 Issue: 1

Genetically modified Schwann cells producing glial cell line-derived neurotrophic factor inhibit neuronal apoptosis in rat spinal cord injury.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shao, Guoxi Liu, Guomin Wang, Xukai Liu, Qinyi
Description	Author Affiliation: Liu G ( Department of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.); Wang X ( Department of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.); Shao G ( Department of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.); Liu Q ( Department of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.)
Abstract	Schwann cells (SCs) are the major cells constituting the peripheral nerve structure and function, and also secret a variety of neurotrophic factors. Schwann cell (SC) transplantation has recently emerged as a promising therapeutic strategy for spinal cord injury (SCI). In the present study, the ability of genetically modified SCs producing high levels of glial cell linederived neurotrophic factor (GDNF) to promote spinal cord repair was assessed. The GDNF gene was transduced into SCs. The engineered SCs were characterized by their ability to express and secrete biologically active GDNF, which was shown to inhibit apoptosis of primary rat neurons induced by radiation, and upregulate the expression of Bcell lymphoma 2 (Bcl2) and downregulate the expression of Bcl2 associated X protein (Bax) in vitro. Following SC implantation into the spinal cord of adult rats with SCI induced by weightdrop impact, the survival of rats with transplanted SCs, histology of the spinal cord and expression levels of Bcl2 and Bax were examined. Transplantation of unmodified and genetically modified SCs producing GDNF attenuated SCI by inhibiting apoptosis via the Bcl2/Bax pathways. The genetically modified SCs demonstrated markedly improved recovery of SCI as compared with unmodified SCs. The present study combined the outgrowthpromoting property of SCs with the neuroprotective effects of overexpressed GDNF and identified this as a potential novel therapeutic strategy for SCI.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	4
Volume Number	9
Language	English
Publisher	Spandidos Publications
Publisher Date	2014-04-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Apoptosis Genetic Therapy Glial Cell Line-derived Neurotrophic Factor Genetics Therapeutic Use Neurons Pathology Schwann Cells Transplantation Spinal Cord Injuries Therapy Animals Coculture Techniques Rats, Wistar Metabolism Spinal Cord Bcl-2-associated X Protein Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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Genetically modified Schwann cells producing glial cell line-derived neurotrophic factor inhibit neuronal apoptosis in rat spinal cord injury.

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