NDLI: Analysis of blood flow and local expression of angiogenesisassociated growth factors in infected wounds treated with negative pressure wound therapy.

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Analysis of blood flow and local expression of angiogenesisassociated growth factors in infected wounds treated with negative pressure wound therapy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xia, Cheng-Yan Yu, Ai-Xi Qi, Baiwen Zhou, Min Wang, Wei-Yang Li, Zong-Huan
Description	Author Affiliation: Xia CY ( Department of MicroOrthopaedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China.); Yu AX ( Department of MicroOrthopaedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China.); Qi B ( Department of MicroOrthopaedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China.); Zhou M ( Department of MicroOrthopaedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China.); Li ZH ( Department of MicroOrthopaedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China.); Wang WY ( Department of MicroOrthopaedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China.)
Abstract	Angiogenesis is involved in the wound healing process. Increased angiogenesis and blood flow constitute a major mechanism of negative pressure wound therapy (NPWT), which has been shown to facilitate the healing of infected wounds. However, the effect on the expression of angiogensisrelated growth factor remains unknown. The goal of the current study was to investigate the angiogenic factor levels prior to and following NPWT in infected wounds. A total of 20 patients with infected wounds treated with NPWT were included in the study. Patients acted as their own control; the postoperative measurements of patients were considered as the experimental group, while preoperative measurements were considered as the controlled group. Blood flow was recorded prior to and during NPWT. A total of 10 angiogensisrelated growth factors were detected using a protein biochip array to analyze the change in protein levels prior to NPWT, and on the third day during NPWT. All wounds were successfully reconstructed by skin grafting or using local flaps following NPWT. NPWT resulted in significantly increased blood flow in the wound. There was a significant increase in vascular endothelial growth factor (VEGF), EGF, plateletderived growth factor and angiotesin2 following NPWT, while basic fibroblast growth factor decreased significantly. NPWT affects the local expression of angiogenesisassociated growth factors, which represents another mechanism to explain how NPWT accelerates wound healing.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	5
Volume Number	9
Language	English
Publisher	Spandidos Publications
Publisher Date	2014-05-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Intercellular Signaling Peptides And Proteins Metabolism Negative-pressure Wound Therapy Neovascularization, Physiologic Wound Healing Wounds And Injuries Therapy Genetics Proteome Proteomics Regional Blood Flow Etiology Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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