NDLI: Identification of the typical miRNAs and target genes in hepatocellular carcinoma.

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Identification of the typical miRNAs and target genes in hepatocellular carcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liang, Ping Han, Keqiang Huang, Xiaobing Zhao, Hongzhi Yang, Tonghan Li, Jing Wang, Liang Zheng, Lu Li, Yuming
Description	Author Affiliation: Han K ( Department of Hepatobiliary Surgery, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, P.R. China.); Li J ( Department of Hepatobiliary Surgery, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, P.R. China.); Zhao H ( Department of Hepatobiliary Surgery, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, P.R. China.); Liang P ( Department of Hepatobiliary Surgery, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, P.R. China.); Huang X ( Department of Hepatobiliary Surgery, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, P.R. China.); Zheng L ( Department of Hepatobiliary Surgery, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, P.R. China.); Li Y ( Department of Hepatobiliary Surgery, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, P.R. China.); Yang T ( Department of Hepatobiliary Surgery, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, P.R. China.); Wang L ( Department of Hepatobiliary Surgery, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, P.R. China.)
Abstract	The aim of the present study was to identify miRNAs that were differentially expressed in hepatocellular carcinoma (HCC) by comparing normal and cancer tissue samples and to analyze the correlation of the target genes and HCC. The gene expression profile of GSE31383 was downloaded from the Gene Expression Omnibus database, including 19 samples, 9 normal and 10 from HCC tissue samples. The differentiallyexpressed miRNAs were identified with packages in R language and further analyzed using bioinformatics methods. Firstly, the verified targets of miRNAs were integrated in two miRNA databases: miRecords and miRTarBase, and the targets of the differentiallyexpressed miRNAs were obtained. The software STRING was then used to construct the interaction network of target genes. Finally, a functional enrichment analysis of the genes in the interaction network was conducted using the software Gestalt. Typical miR224 and miR214 were identified by comparing normal and cancer samples, each of which obtained 14 and 8 target genes, respectively. The functional enrichment analysis of the targets in the two groups highlighted the intracellular signaling cascade. In conclusion, the featured miRNAs (the upregulated miRNA224 and downregulated miRNA214) and their target genes are significant in the occurrence and development of HCC, which is likely to be significant for the identification of therapeutic targets and biomarkers to aid in the treatment of HCC.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	1
Volume Number	10
Language	English
Publisher	Spandidos Publications
Publisher Date	2014-07-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Carcinoma, Hepatocellular Genetics Liver Neoplasms Micrornas Metabolism Pathology Databases, Genetic Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Regulatory Networks Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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