NDLI: Photoprotective effect of arctiin against ultraviolet B-induced damage in HaCaT keratinocytes is mediated by microRNA expression changes.

Please wait, while we are loading the content...

Radix Hedysari polysaccharide suppresses lipid metabolism dysfunction in a rat model of nonalcoholic fatty liver disease via adenosine monophosphateactivated protein kinase pathway activation.

miR-137 regulates the migration of human umbilical vein endothelial cells by targeting ephrin-type A receptor 7.

Silencing of hypoxiainducible adrenomedullin using RNA interference attenuates hepatocellular carcinoma cell growth in vivo.

Nucleolin identified by comparative massspectra analysis is a potential marker for invasive progression of hepatocellular carcinoma.

Inhibitory effects of Picrasma quassioides (D.Don) Benn. on airway inflammation in a murine model of allergic asthma.

In vitro selection and identification of ssDNA aptamers recognizing the Ras protein.

Podoplaninpositive cancer cells at the edge of esophageal squamous cell carcinomas are involved in invasion.

Integrative genomic analyses of secreted protein acidic and rich in cysteine and its role in cancer prediction.

Experimental chondrocyte hypertrophy is promoted by the activation of discoidin domain receptor 2.

Antiinflammatory effects of Panax notoginseng saponins ameliorate acute lung injury induced by oleic acid and lipopolysaccharide in rats.

Diabetes mellitus potentiates diffuse large Bcell lymphoma via high levels of CCL5.

Carbon dioxidepneumoperitoneum in rats reduces ischemia/reperfusioninduced hepatic apoptosis and inflammatory responses by stimulating sensory neurons.

A familial lateonset hereditary ataxia mimicking pontocerebellar hypoplasia caused by a novel TSEN54 mutation.

Effect of Substance P on type II alveolar epithelial cells exposed to hyperoxia and its regulation of the Sonic hedgehog signaling pathway.

Expression and effect of CXCL14 in colorectal carcinoma.

Bioactive components of Glycyrrhiza uralensis mediate drug functions and properties through regulation of CYP450 enzymes.

Arsenic trioxide and bortezomib interact synergistically to induce apoptosis in chronic myelogenous leukemia cells resistant to imatinib mesylate through Bcr/Abldependent mechanisms.

Radioprotective effect of a pan-caspase inhibitor in a novel model of radiation injury to the nucleus of the abducens nerve.

MicroRNA-26a inhibits cell proliferation and invasion of cervical cancer cells by targeting protein tyrosine phosphatase type IVA 1.

Inhibitory effects of hydroxysafflor yellow A on PDGFBBinduced proliferation and migration of vascular smooth muscle cells via mediating Akt signaling.

Screening of hepatocyte proteins binding with Cterminally truncated surface antigen middle protein of hepatitis B virus (MHBst167) by a yeast twohybrid system.

Diagnosis of ABCB11 gene mutations in children with intrahepatic cholestasis using high resolution melting analysis and direct sequencing.

Attenuated ability of BACE1 to cleave the amyloid precursor protein via silencing long noncoding RNA BACE1AS expression.

Tumor necrosis factor- induces interleukin-34 expression through nuclear factorκB activation in MC3T3-E1 osteoblastic cells.

Elevated expression of SLC34A2 inhibits the viability and invasion of A549 cells.

Knockdown of OCT4 suppresses the growth and invasion of pancreatic cancer cells through inhibition of the AKT pathway.

Pattern of microRNA expression associated with different stages of alcoholic liver disease in rat models.

A SNaPshot assay for the rapid and simple detection of hepatitis B virus genotypes.

Transforming growth factorß1 reduces apoptosis via autophagy activation in hepatic stellate cells.

Elevated intracranial dopamine impairs the glutamatenitric oxidecyclic guanosine monophosphate pathway in cortical astrocytes in rats with minimal hepatic encephalopathy.

Apogossypolone inhibits the proliferation of LNCaP cells in vitro and in vivo.

Year: 2014 Volume: 10 Issue: 2

Year: 2014 Volume: 10 Issue: 1

Photoprotective effect of arctiin against ultraviolet B-induced damage in HaCaT keratinocytes is mediated by microRNA expression changes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hong, Jin Tae Lee, Su-Jae Lee, Kwang Sik Lee, Bo Mi Lee, Ghang Tai Lee, Kun Kook An, Sungkwan Kim, Soo-Yeon An, In-Sook Hahn, Hyung Jin Lee, Na Kyeong Ahn, Kyu Joong Bae, Seunghee Cha, Hwa Jun
Description	Author Affiliation: Cha HJ ( Korea Institute for Skin and Clinical Sciences and Molecular-Targeted Drug Research Center, Konkuk University, Seoul 143-701, Republic of Korea.); Lee GT ( Songpa R&D Center, Coreana Cosmetics Co., Ltd., Cheonan, Chungcheongnam-do 330-833, Republic of Korea.); Lee KS ( Songpa R&D Center, Coreana Cosmetics Co., Ltd., Cheonan, Chungcheongnam-do 330-833, Republic of Korea.); Lee KK ( Songpa R&D Center, Coreana Cosmetics Co., Ltd., Cheonan, Chungcheongnam-do 330-833, Republic of Korea.); Hong JT ( College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, Chungcheongbuk-do 361-763, Republic of Korea.); Lee NK ( Korea Institute for Skin and Clinical Sciences and Molecular-Targeted Drug Research Center, Konkuk University, Seoul 143-701, Republic of Korea.); Kim SY ( Korea Institute for Skin and Clinical Sciences and Molecular-Targeted Drug Research Center, Konkuk University, Seoul 143-701, Republic of Korea.); Lee BM ( Korea Institute for Skin and Clinical Sciences and Molecular-Targeted Drug Research Center, Konkuk University, Seoul 143-701, Republic of Korea.); An IS ( Korea Institute for Skin and Clinical Sciences and Molecular-Targeted Drug Research Center, Konkuk University, Seoul 143-701, Republic of Korea.); Hahn HJ ( Department of Dermatology, Konkuk University School of Medicine, Seoul 143-701, Republic of Korea.); Ahn KJ ( Department of Dermatology, Konkuk University School of Medicine, Seoul 143-701, Republic of Korea.); Lee SJ ( Department of Chemistry, Hanyang University, Seoul 133-791, Republic of Korea.); An S ( Korea Institute for Skin and Clinical Sciences and Molecular-Targeted Drug Research Center, Konkuk University, Seoul 143-701, Republic of Korea.); Bae S ( Korea Institute for Skin and Clinical Sciences and Molecular-Targeted Drug Research Center, Konkuk University, Seoul 143-701, Republic of Korea.)
Abstract	Human keratinocytes are located in the outermost skin layer and thus particularly vulnerable to ultraviolet B (UVB) radiation exposure. Previous studies have focused on the cellular and molecular perspectives of UVB-induced keratinocyte damage. In the present study, it was demonstrated that pretreatment with the phytochemical arctiin, one of the lignin compounds, protects human HaCaT keratinocytes from UVB-mediated damage. Biochemical assays revealed that UVB-induced cytotoxicity and cell death were significantly reduced in arctiin-pretreated HaCaT cells. In addition, arctiin promoted the wound healing and DNA repair properties of keratinocytes. The photoprotective effects of arctiin were associated with changes in the expression levels of specific microRNAs (miRNAs) in HaCaT cells. A bioinformatics analysis demonstrated that the miRNAs were functionally involved in cancer, cell cycle, and Wnt and mitogen-activated protein kinase signaling pathways. In the present study, the results from the cellular and molecular assays demonstrated a novel role for arctiin in UVB protection in keratinocytes, which is mediated by miRNA responses and the suppression of UVB-induced cell death. Furthermore, arctiin is implicated as a potential chemopreventive agent through UVB protection of keratinocytes.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	3
Volume Number	10
Language	English
Publisher	Spandidos Publications
Publisher Date	2014-09-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Furans Pharmacology Glucosides Keratinocytes Drug Effects Radiation Effects Protective Agents Ultraviolet Rays Adverse Effects Cell Cycle Cell Death Cell Line Computational Biology Dna Repair Metabolism Micrornas Genetics Mitogen-activated Protein Kinases Skin Cytology Wnt Signaling Pathway Wound Healing Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Protective effect of pyruvate against UVB-induced damage in HaCaT human keratinocytes.

MiR-23a regulates DNA damage repair and apoptosis in UVB-irradiated HaCaT cells.

Calcitonin gene-related peptide increases proliferation of human HaCaT keratinocytes by activation of MAP kinases.

Bovine colostrum promotes growth and migration of the human keratinocyte HaCaT cell line.

Protective effects of kappa-ca3000+CP against ultraviolet-induced damage in HaCaT and MEF cells.

Toll-like receptor 4 has an essential role in early skin wound healing.

Desmoglein 3-Dependent Signaling Regulates Keratinocyte Migration and Wound Healing.

Mycosporine-Like Amino Acids Promote Wound Healing through Focal Adhesion Kinase (FAK) and Mitogen-Activated Protein Kinases (MAP Kinases) Signaling Pathway in Keratinocytes

Protective effect of triphlorethol-A against ultraviolet B-mediated damage of human keratinocytes.

Photoprotective effect of arctiin against ultraviolet B-induced damage in HaCaT keratinocytes is mediated by microRNA expression changes.

Similar Documents

Protective effect of pyruvate against UVB-induced damage in HaCaT human keratinocytes.

MiR-23a regulates DNA damage repair and apoptosis in UVB-irradiated HaCaT cells.

Calcitonin gene-related peptide increases proliferation of human HaCaT keratinocytes by activation of MAP kinases.

Bovine colostrum promotes growth and migration of the human keratinocyte HaCaT cell line.

Protective effects of kappa-ca3000+CP against ultraviolet-induced damage in HaCaT and MEF cells.

Toll-like receptor 4 has an essential role in early skin wound healing.

Desmoglein 3-Dependent Signaling Regulates Keratinocyte Migration and Wound Healing.

Mycosporine-Like Amino Acids Promote Wound Healing through Focal Adhesion Kinase (FAK) and Mitogen-Activated Protein Kinases (MAP Kinases) Signaling Pathway in Keratinocytes

Protective effect of triphlorethol-A against ultraviolet B-mediated damage of human keratinocytes.

Photoprotective effect of arctiin against ultraviolet B-induced damage in HaCaT keratinocytes is mediated by microRNA expression changes.