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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gao, Yi Xu, Danfeng Chen, Jie Liu, Yushan Wang, Zhijun |
| Description | Author Affiliation: Chen J ( Department of Urology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.); Wang Z ( Department of Urology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.); Xu D ( Department of Urology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.); Liu Y ( Department of Urology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.); Gao Y ( Department of Urology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China.) |
| Abstract | Aquaporins (AQPs) are known to be important in cancer progression. The present study used a cDNA microarray to demonstrate that AQP3, a member of the AQP family, was overexpressed in prostate cancer cells. In order to determine the role of AQP3 in prostate cancer, AQP3 expression was silenced by transfection with small interfering RNA, following which wound healing and invasion assays were conducted in DU145 and PC3 cells. Notably, the results showed that silencing of AQP3 suppressed prostate cancer cell motility and invasion. The possible mechanisms underlying the AQP3enhanced motility and invasion of prostate cancer cells was also investigated. Knockdown of AQP3 expression was shown to reduce extracellular signalregulated kinase 1/2 (ERK1/2) activation in DU145 and PC3 cells. Blocking the ERK pathway inhibited AQP3mediated motility and invasion of these cells. Finally, the results demonstrated that AQP3 upregulated matrix metalloproteinase3 (MMP3) expression and secretion in prostate cancer cells via activation of the ERK pathway. In conclusion, the present study suggests that AQP3 induces ERK1/2 activation, thereby increasing MMP3 expression and secretion, which in turn promotes prostate cancer cell motility and invasion. Thus, AQP3 may be considered to be a potential therapeutic target for prostate cancer. |
| ISSN | 17912997 |
| e-ISSN | 17913004 |
| Journal | Molecular Medicine Reports |
| Issue Number | 4 |
| Volume Number | 11 |
| Language | English |
| Publisher | Spandidos Publications |
| Publisher Date | 2015-04-01 |
| Publisher Place | Greece |
| Access Restriction | Open |
| Subject Keyword | Aquaporin 3 Genetics Matrix Metalloproteinase 3 Secretion Mitogen-activated Protein Kinase 1 Metabolism Mitogen-activated Protein Kinase 3 Prostatic Neoplasms Cell Line, Tumor Cell Movement Cluster Analysis Gene Expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Map Kinase Signaling System Discipline Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology |
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