NDLI: Dynamic correlation between induction of the expression of heme oxygenase-1 and hepatitis B viral replication.

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Increased oxidative stress and disrupted small intestinal tight junctions in cigarette smoke-exposed rats.

Polymorphism in the NLRP3 inflammasome-associated EIF2AK2 gene and inflammatory bowel disease.

Yes-associated protein regulates the growth of human non-small cell lung cancer in response to matrix stiffness.

Cetuximab-induced insulin-like growth factor receptor I activation mediates cetuximab resistance in gastric cancer cells.

p53 upregulated modulator of apoptosis sensitizes drug-resistant U251 glioblastoma stem cells to temozolomide through enhanced apoptosis.

Expression of circulating microRNA-1 and microRNA-133 in pediatric patients with tachycardia.

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Knockdown of yes-associated protein inhibits proliferation and downregulates large tumor suppressor 1 expression in MHCC97H human hepatocellular carcinoma cells.

Von Hippel-Lindau gene expression on the human fallopian tube epithelium during the menstrual cycle.

Single nucleotide polymorphisms in interleukin-6 and their association with venous thromboembolism.

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Electroacupuncture pretreatment induces tolerance against cerebral ischemia/reperfusion injury through inhibition of the autophagy pathway.

Neuronic autophagy contributes to p-connexin 43 degradation in hippocampal astrocytes following traumatic brain injury in rats.

Effect of oxidized low-density lipoprotein on the expression of the prorenin receptor in human aortic smooth muscle cells.

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Association of hsa-miR145 overexpression in human testicular cells with male infertility.

Association between the ABCC11 gene polymorphism and the expression of apolipoprotein D by the apocrine glands in axillary osmidrosis.

Role of microRNAs in skeletal muscle development and rhabdomyosarcoma (review).

Matrine inhibits the migratory and invasive properties of nasopharyngeal carcinoma cells.

Screening and functional pathway analysis of genes associated with pediatric allergic asthma using a DNA microarray.

Dynamic correlation between induction of the expression of heme oxygenase-1 and hepatitis B viral replication.

Tumor formation and drug resistance properties of human glioblastoma side population cells.

Correlation between microRNA21 and sprouty homolog 2 gene expression in multiple myeloma.

Poly (ADP-ribose) polymerase- and cytochrome c-mediated apoptosis induces hepatocyte injury in a rat model of hyperammonia-induced hepatic failure

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Inhibition of mechanical stress-induced hypertrophic scar inflammation by emodin.

Early metabolic changes following ischemia onset in rats: an in vivo diffusion-weighted imaging and 1H-magnetic resonance spectroscopy study at 7.0 T.

Oleuropein induces apoptosis via activation of caspases and suppression of phosphatidylinositol 3-kinase/protein kinase B pathway in HepG2 human hepatoma cell line.

Activin A regulates proliferation, invasion and migration in osteosarcoma cells.

High GOLPH3 expression is associated with poor prognosis and invasion of hepatocellular carcinoma.

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microRNA2993p inhibits laryngeal cancer cell growth by targeting human telomerase reverse transcriptase mRNA.

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Involvement of Fanconi anemia genes FANCD2 and FANCF in the molecular basis of drug resistance in leukemia.

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Long noncoding RNAs: novel links in respiratory diseases (review).

Side population cells and drug resistance in breast cancer.

Role of the complement anaphylatoxin C5a-receptor pathway in atopic dermatitis in mice.

A disintegrin and metallproteinase 15 knockout decreases migration of fibroblast-like synoviocytes and inflammation in rheumatoid arthritis.

Polyamines modulate the roscovitine-induced cell death switch decision autophagy vs. apoptosis in MCF-7 and MDA-MB-231 breast cancer cells.

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Effects of ethanol on the expression of caveolin-1 in HepG2 cells.

Apoptosis of Bel-7402 human hepatoma cells induced by a ruthenium(II) complex coordinated by cordycepin through the p53 pathway.

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2D-1H proton magnetic resonance spectroscopic imaging study on brain metabolite alterations in patients with diabetic hypertension.

Linear polyethylenimine-plasmid DNA nanoparticles are ototoxic to the cultured sensory epithelium of neonatal mice.

Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis in rats.

Antitumor effect and mechanism of action of a tumor-targeting recombinant human tumor necrosis factor- fusion protein mediated by urokinase.

Ovarian cancer stem-like cells elicit the polarization of M2 macrophages.

Atorvastatin induces autophagic cell death in prostate cancer cells in vitro.

Effects of hyperbaric oxygen therapy on NACHT domain-leucine-rich-repeat- and pyrin domain-containing protein 3 inflammasome expression in rats following spinal cord injury.

MicroRNA-181 targets Yin Yang 1 expression and inhibits cervical cancer progression.

Analysis of mechanical ventilation and lipopolysaccharideinduced acute lung injury using DNA microarray analysis.

Stromal cell-derived factor-1 G801A polymorphism and the risk factors for cervical cancer.

Sclareol, a plant diterpene, exhibits potent antiproliferative effects via the induction of apoptosis and mitochondrial membrane potential loss in osteosarcoma cancer cells.

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ß-Adrenergic stimulation activates protein kinase CÎµ and induces extracellular signal-regulated kinase phosphorylation and cardiomyocyte hypertrophy.

Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo.

Advanced glycation endproducts affect the cytoskeletal structure of rat glomerular endothelial cells via the Rasrelated C3 botulinum toxin substrate 1 signaling pathway.

Inflammation and pathological damage to the lungs of mice are only partially reversed following smoking cessation on subacute exposure to cigarette smoke.

A long-acting ß2-adrenergic agonist increases the expression of muscarine cholinergic subtype3 receptors by activating the ß2-adrenoceptor cyclic adenosine monophosphate signaling pathway in airway smooth muscle cells.

Hypoxia-induced microRNA-155 promotes fibrosis in proximal tubule cells.

PUFA diets alter the microRNA expression profiles in an inflammation rat model.

Oxymatrine inhibits the proliferation of prostate cancer cells in vitro and in vivo.

Protective effect of Flt3L on organ structure during advanced multiorgan dysfunction syndrome in mice.

Identification of genes and transcription factors associated with glucocorticoid response in lens epithelial cells.

Association between oxidative DNA damage and the expression of 8-oxoguanine DNA glycosylase 1 in lung epithelial cells of neonatal rats exposed to hyperoxia

Chloroform fraction of Euphorbia maculata has antiplatelet activity via suppressing thromboxane B2 formation.

Inhibition of microRNA-25 by tumor necrosis factor is critical in the modulation of vascular smooth muscle cell proliferation.

Naotaifang extract treatment results in increased ferroportin expression in the hippocampus of rats subjected to cerebral ischemia.

Endocrine glandderived vascular endothelial growth factor modulates proliferation, apoptosis and migration in pancreatic cancer cells.

Effects of A2BR on the biological behavior of mouse renal fibroblasts during hypoxia.

Inhibition of monocyte chemoattractant peptide-1 decreases secondary spinal cord injury.

Safflower polysaccharide inhibits the proliferation and metastasis of MCF-7 breast cancer cell.

Proteins S100A8 and S100A9 are potential biomarkers for renal cell carcinoma in the early stages: Results from a proteomic study integrated with bioinformatics analysis

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Zinc ion implantationdeposition technique improves the osteoblast biocompatibility of titanium surfaces.

Curcumin inhibits autophagy and apoptosis in hypoxia/reoxygenation-induced myocytes.

MicroRNA-185 downregulates androgen receptor expression in the LNCaP prostate carcinoma cell line.

Intercellular transfer of messenger RNAs in multiorgan tumorigenesis by tumor cell-derived exosomes.

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Dynamic correlation between induction of the expression of heme oxygenase-1 and hepatitis B viral replication.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wu, Yi-Hang Yu, Xiao-Ping Dai, Ling-Hao Shen, Yu-Ming Hu, Hua-Jun Zhang, Hong-Li
Description	Author Affiliation: Shen YM ( Department of Pharmacy, Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, College of Life Sciences, China Jiliang University, Hangzhou, Zhejiang 310018, P.R. China.); Zhang HL ( Department of Pharmacy, Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, College of Life Sciences, China Jiliang University, Hangzhou, Zhejiang 310018, P.R. China.); Wu YH ( Department of Pharmacy, Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, College of Life Sciences, China Jiliang University, Hangzhou, Zhejiang 310018, P.R. China.); Yu XP ( Department of Pharmacy, Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, College of Life Sciences, China Jiliang University, Hangzhou, Zhejiang 310018, P.R. China.); Hu HJ ( Department of Pharmacy, Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, College of Life Sciences, China Jiliang University, Hangzhou, Zhejiang 310018, P.R. China.); Dai LH ( Department of Pharmacy, Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, College of Life Sciences, China Jiliang University, Hangzhou, Zhejiang 310018, P.R. China.)
Abstract	Heme oxygenase1 (HO1) possesses significant potential as a drug target for hepatitis B, which may be transferable to patient therapy. The aim of the present study was to clarify the dynamic correlation between the hepatitis B virus (HBV) and HO1. The levels of HBV replication and expression of HO1 were investigated in HepG2.2.15 hepatoma cells following exposure to 550 µM hemin for 16 days. The mRNA expression levels of HO1 were then detected using reverse transcriptionquantitative polymerase chain reaction (RTqPCR). HBV replication levels were determined by enzymeimmunoassay and a PCRfluorescence quantitation assay. The results of the present study demonstrated that the mRNA expression levels of HO1 increased in a dosedependent manner in the HepG2.2.15 cells, following exposure to 550 µM hemin. The mRNA expression levels of HO1 reached a peak following exposure of the cells to hemin for three days, subsequently the expression of HO1 decreased. Following exposure to hemin at an optimal concentration of 50 µM for 16 days, the levels of the hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) in the cells were significantly reduced. This marked reduction in the expression of HBsAg and HBeAg reached its peak on the first day, following which the inhibition weakened as the duration of exposure increased. In addition, the inhibition of HBV DNA replication increased with the a longer duration of exposure. Furthermore, HBV DNA levels were significantly decreased following exposure to hemin for 36 days. In conclusion, the present study demonstrated that induced expression of HO1 interfered with HBV replication in a dose and timedependent manner, implying that a reduction of the HBV viral load may contribute to upregulation in the expression of HO1.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	6
Volume Number	11
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-06-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Heme Oxygenase-1 Metabolism Hepatitis B Virus Physiology Dna, Viral Down-regulation Drug Effects Genetics Hemin Toxicity Hep G2 Cells Hepatitis B Surface Antigens Hepatitis B e Antigens Rna, Messenger Transcription, Genetic Virus Replication Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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