NDLI: Synergistic effect of a tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 coexpression vector on the proliferation of rat vascular smooth muscle cells.

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Oxymatrine suppresses proliferation and facilitates apoptosis of human ovarian cancer cells through upregulating microRNA29b and downregulating matrix metalloproteinase2 expression.

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Molecular cloning and characterization of presenilin gene in Bombyx mori.

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Immunohistochemical analysis of phosphorylated mammalian target of rapamycin and its downstream signaling components in invasive breast cancer.

Identification of genes associated with osteoarthritis by microarray analysis.

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A novel endoplasmic reticulum stressinduced apoptosis model using tunicamycin in primary cultured neonatal rat cardiomyocytes.

MicroRNA21 regulates the expression of BTG2 in HepG2 liver cancer cells.

Hepatitis C virus NS3 protein modulates the biological behaviors of malignant hepatocytes by altering the expression of host cell microRNA.

MicroRNA197 reverses the drug resistance of fluorouracilinduced SGC7901 cells by targeting mitogenactivated protein kinase 1.

1Oacetylbritannilactone combined with gemcitabine elicits growth inhibition and apoptosis in A549 human nonsmall cell lung cancer cells.

Ursolic acid from Trailliaedoxa gracilis induces apoptosis in medullary thyroid carcinoma cells.

Gonadotropin-releasing hormone inhibits the proliferation and motility of nasopharyngeal carcinoma cells

Gene therapy for ocular diseases meditated by ultrasound and microbubbles (Review).

Anticancer and apoptotic activities of oleanolic acid are mediated through cell cycle arrest and disruption of mitochondrial membrane potential in HepG2 human hepatocellular carcinoma cells.

Expression of nephrin in the human placenta and fetal membranes.

Hypoxia promotes the proliferation of MC3T3-E1 cells via the hypoxia-inducible factor-1 signaling pathway.

Carvacrol protects against spinal cord injury in rats via suppressing oxidative stress and the endothelial nitric oxide synthase pathway.

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Comparison of ovarian cancer markers in endometriosis favours HE4 over CA125.

Biological characteristics of the A1762T/G1764A mutant strain of hepatitis B virus in vivo.

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Two faces of the estrogen metabolite 2-methoxyestradiol in vitro and in vivo.

Minocycline inhibits PARP1 expression and decreases apoptosis in diabetic retinopathy.

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Galectin-3-induced oxidized low-density lipoprotein promotes the phenotypic transformation of vascular smooth muscle cells.

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Functional analysis of the nasopharyngeal carcinoma primary tumorassociated gene interaction network.

Emodin inhibits angiogenesis in pancreatic cancer by regulating the transforming growth factor-ß/drosophila mothers against decapentaplegic pathway and angiogenesis-associated microRNAs.

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Probiotics modify human intestinal mucosa-associated microbiota in patients with colorectal cancer.

Optimal compressive force accelerates osteoclastogenesis in RAW264.7 cells.

Ascorbic acid inhibits TPA-induced HL-60 cell differentiation by decreasing cellular H2O2 and ERK phosphorylation.

Activated farnesoid X receptor attenuates apoptosis and liver injury in autoimmune hepatitis.

Effects of Xray irradiation in combination with ascorbic acid on tumor control.

Zinc deficiency during in vitro maturation of porcine oocytes causes meiotic block and developmental failure.

Proinflammatory effects of the hemagglutinin protein of the avian influenza A (H7N9) virus and microRNAmediated homeostasis response in THP1 cells.

House dust mite allergens mediate the activation of ckit in dendritic cells via Tolllike receptor 2.

Involvement of an intracellular vesicular transport process in naked-sgRNA-mediated TRUE gene silencing.

MicroRNA506 participates in pancreatic cancer pathogenesis by targeting PIM3.

Histopathology of melanosis coli and determination of its associated genes by comparative analysis of expression microarrays.

Helicobacter pylori cytotoxin-associated gene A activates tumor necrosis factor- and interleukin-6 in gastric epithelial cells through P300/CBP-associated factor-mediated nuclear factor-κB p65 acetylation.

Long non-coding RNA HOTAIR: A novel oncogene (Review).

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Crossreactivity between group-5 and -21 mite allergens from Dermatophagoides farinae, Tyrophagus putrescentiae and Blomia tropicalis.

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Determination of ABO blood group genotypes using the realtime loopmediated isothermal amplification method.

Immunological characterization and verification of recombinant streptococcal protein G.

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Synergistic neuroprotective effect of microglialconditioned media treated with geniposide and ginsenoside Rg1 on hypoxia injured neurons.

Evaluation of reference gene suitability for quantitative expression analysis by quantitative polymerase chain reaction in the mandibular condyle of sheep.

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Elastic large muscular vessel wall engineered with bone marrowderived cells under pulsatile stimulation in a bioreactor.

Chondrogenic differentiation of bone marrowderived stem cells cultured in the supernatant of elastic cartilage cells.

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Autophagy inhibition enhances isorhamnetininduced mitochondriadependent apoptosis in nonsmall cell lung cancer cells.

Nuclear transcription factor CDX2 inhibits gastric cancercell growth and reverses epithelialtomesenchymal transition in vitro and in vivo.

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Small interfering RNA-induced silencing of galectin-3 inhibits the malignant phenotypes of osteosarcoma in vitro.

16S rDNA PCR-DGGE and sequencing in the diagnosis of neonatal late-onset septicemia.

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Oxidative damage to human parametrial ligament fibroblasts induced by mechanical stress.

MicroRNA20a promotes the proliferation and cell cycle of human osteosarcoma cells by suppressing early growth response 2 expression.

Association of genetic variants with dyslipidemia.

1q21.1 microduplication in a patient with mental impairment and congenital heart defect.

Lentiviral-mediated growth-associated protein-43 modification of bone marrow mesenchymal stem cells improves traumatic optic neuropathy in rats.

Ponicidin suppresses HT29 cell growth via the induction of G1 cell cycle arrest and apoptosis.

Networks of micrornas and genes in acute lymphoblastic leukemia.

Effects of brainderived neurotrophic factor and neurotrophin3 on the neuronal differentiation of rat adiposederived stem cells.

Stimulation of RAW264.7 macrophages by sulfated Escherichia coli K5 capsular polysaccharide in vitro.

Vitamin C attenuates the toxic effect of aristolochic acid on renal tubular cells via decreasing oxidative stressmediated cell death pathways.

Inactivation of INK4a and ARF induces myocardial proliferation and improves cardiac repair following ischemiareperfusion.

MicroRNA-19a mediates gastric carcinoma cell proliferation through the activation of nuclear factor-κB.

Roles of microRNA-146a and microRNA-181b in regulating the secretion of tumor necrosis factor-α and interleukin-1β in silicon dioxide-induced NR8383 rat macrophages

Transplantation of vascular endothelial growth factor 165transfected endothelial progenitor cells for the treatment of limb ischemia.

Gremlin 2 inhibits adipocyte differentiation through activation of Wnt/ß-catenin signaling.

MicroRNA214 promotes proliferation and inhibits apoptosis via targeting Bax in nasopharyngeal carcinoma cells.

MicroRNA133a and microRNA326 cocontribute to hepatocellular carcinoma 5fluorouracil and cisplatin sensitivity by directly targeting Bcell lymphomaextra large.

Cytotoxic and apoptogenic effects of Strobilanthes crispa Blume extracts on nasopharyngeal cancer cells.

Practical assessment of the quantification of atherosclerotic lesions in apoEâ »/â » mice.

Dickkopfrelated protein 1 induces angiogenesis by upregulating vascular endothelial growth factor in the synovial fibroblasts of patients with temporomandibular joint disorders.

A genome-wide study of DNA methylation modified by epigallocatechin-3-gallate in the CAL-27 cell line.

NMyc downstreamregulated gene 2 suppresses the proliferation of T24 human bladder cancer cells via induction of oncosis.

Association between xanthine dehydrogenase tag single nucleotide polymorphisms and essential hypertension.

Effect of thymosin 1 on the phenotypic and functional maturation of dendritic cells from children with acute lymphoblastic leukemia.

Functional and proteinprotein interaction network analysis of colorectal cancer induced by ulcerative colitis.

Coupled aggregation of mitochondrial single-strand DNA-binding protein tagged with Eos fluorescent protein visualizes synchronized activity of mitochondrial nucleoids.

Molecular docking to explore the possible binding mode of potential inhibitors of thioredoxin glutathione reductase.

Clinical correlation of peripheral CD4+cell subsets, their imbalance and Parkinson's disease.

Characterization of fluorescent NBDcholesterol efflux in THP1derived macrophages.

MicroRNA-210 is upregulated by hypoxia-inducible factor-1 in the stromal cells of giant cell tumors of bone.

Human recombinant endostatin Endostar attenuates hepatic sinusoidal endothelial cell capillarization in CCl4induced fibrosis in mice.

Ethyl acetate extract of Hypericum japonicum induces apoptosis via the mitochondria-dependent pathway in vivo and in vitro.

Effect of FTY720-phosphate on the expression of inflammation-associated molecules in astrocytes in vitro.

Hochuekkito (Buzhongyiqitang), a herbal medicine, enhances cisplatininduced apoptosis in HeLa cells.

Association between liver X receptor- and neuron-derived orphan nuclear receptor-1 in Kupffer cells of C57BL/6 mice during inflammation.

Effect of transcatheter arterial chemoembolization on cellular immune function and regulatory T cells in patients with hepatocellular carcinoma.

MeCP2 controls hippocampal brain-derived neurotrophic factor expression via homeostatic interactions with microRNA132 in rats with depression.

Induction of microRNA-146a is involved in curcumin-mediated enhancement of temozolomide cytotoxicity against human glioblastoma.

An insertion/deletion polymorphism at the microRNA-122 binding site in the interleukin-1 3'-untranslated region is associated with a risk for osteoarthritis.

MEN1 c.8251G>A mutation in a family with multiple endocrine neoplasia type 1: A case report.

Simvastatin promotes alveolar epithelial cell proliferation and attenuates cigarette smokeinduced emphysema in rats.

Rose myrtle (Rhodomyrtus tomentosa) extract and its component, piceatannol, enhance the activity of DNA polymerase and suppress the inflammatory response elicited by UVBinduced DNA damage in skin cells.

Inhibitory effect of zinc on the advanced glycation end product-induced apoptosis of mouse osteoblastic cells.

Decreased expression levels of Nurr1 are associated with chronic inflammation in patients with type 2 diabetes.

An in vitro investigation into the role of bone marrowderived mesenchymal stem cells in the control of disc degeneration.

Effect of CoCl2 on fracture repair in a rat model of bone fracture.

Low expression of DLC1 is predictive of poor therapeutic efficiency of fluoropyrimidine and oxaliplatin as adjuvant chemotherapy in gastric cancer.

Roles of heat shock factor 1 in isoproterenolinduced myocardial fibrosis in mice.

Genetically modified human placentaderived mesenchymal stem cells with FGF2 and PDGFBB enhance neovascularization in a model of hindlimb ischemia.

Derivation and growth characteristics of dental pulp stem cells from patients of different ages.

Nuclear respiratory factor-2 and adenosine triphosphate synapses in rat primary cortical neuron cultures: The key role of adenosine monophosphate-activated protein kinase.

A comparative study of acellular nerve xenografts and allografts in repairing rat facial nerve defects.

Effect of quantum dots on the biological behavior of the EJ human bladder urothelial carcinoma cell line.

Oxidative stress biomarkers and paraoxonase 1 polymorphism frequency in farmers occupationally exposed to pesticides.

Inhibition of microRNA155 relieves sepsisinduced liver injury through inactivating the JAK/STAT pathway.

Oncolytic adenovirusmediated mda7/IL24 expression suppresses osteosarcoma growth and enhances sensitivity to doxorubicin.

MiR214 promotes osteosarcoma tumor growth and metastasis by decreasing the expression of PTEN.

Lentivirusdelivered nemolike kinase small interfering RNA inhibits laryngeal cancer cell proliferation in vitro.

MicroRNA205 promotes the tumorigenesis of nasopharyngeal carcinoma through targeting tumor protein p53-inducible nuclear protein 1.

Synergistic effect of a tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 coexpression vector on the proliferation of rat vascular smooth muscle cells.

SHSST-cyclodextrin complex inhibits TGF-ß/Smad3/CTGF to a greater extent than silymarin in a rat model of carbon tetrachloride-induced liver injury.

Highmobility group box 1 has a prognostic role and contributes to epithelial mesenchymal transition in human hepatocellular carcinoma.

Resveratrol inhibits oligomeric Aß-induced microglial activation via NADPH oxidase.

Raloxifene neutralizes the adverse effects of glutamate on cultured neurons by regulation of calcium oscillations.

K604, a specific acylCoA:cholesterol acyltransferase 1 inhibitor, suppresses proliferation of U251MG glioblastoma cells.

MicroRNA-29a inhibits mesenchymal stem cell viability and proliferation by targeting Roundabout 1.

Expression of microRNA26b and identification of its target gene EphA2 in pituitary tissues in Yanbian cattle.

Prostaglandin E1 protects bone marrow-derived mesenchymal stem cells against serum deprivation-induced apoptosis.

Promoter methylation, mRNA expression of goat tumorassociated genes and mRNA expression of DNA methyltransferase in enzootic nasal tumors.

Mutation analysis of CACNA1S and SCN4A in patients with hypokalemic periodic paralysis.

Effects of rotigaptide (ZP123) on connexin43 remodeling in canine ventricular fibrillation.

Tectonic 1 accelerates gastric cancer cell proliferation and cell cycle progression in vitro.

MicroRNA-34a induces apoptosis in PC12 cells by reducing B-cell lymphoma 2 and sirtuin-1 expression

Fatsioside Ainduced apoptotic death of HepG2 cells requires activation of AMPactivated protein kinase.

Effect of transplanted adiposederived stem cells in mice exhibiting idiopathic pulmonary fibrosis.

Momordica cochinchinensis Spreng. seed extract suppresses breast cancer growth by inducing cell cycle arrest and apoptosis.

Hepatoma-derived growth factor-2 is highly expressed during development and in spinal cord injury.

Activation of proteaseactivated receptor2 is associated with increased expression of inflammatory factors in the adipose tissues of obese mice.

Phenethyl isothiocyanate enhances adriamycininduced apoptosis in osteosarcoma cells.

Essential oil of Artemisia vestita exhibits potent in vitro and in vivo antibacterial activity: Investigation of the effect of oil on biofilm formation, leakage of potassium ions and survival curve measurement.

A duplication upstream of SOX9 was not positively correlated with the SRYnegative 46,XX testicular disorder of sex development: A case report and literature review.

Effects of Dangkwisoosan, a traditional herbal medicine for treating pain and blood stagnation, on the pacemaker activities of cultured interstitial cells of Cajal.

Molecular screening of the LPCAT1 gene in patients with retinitis pigmentosa without defined mutations in known retinitis pigmentosa genes.

Expression of protein kinase C isoforms in cultured human Tenon's capsule fibroblast cells.

Metformin suppresses intrahepatic coagulation activation in mice with lipopolysaccharide/Dgalactosamineinduced fulminant hepatitis.

Gua Lou Gui Zhi decoction attenuates poststroke spasticity via the modulation of GABAB receptors.

Small nuclear ribonucleoprotein associated polypeptide N accelerates cell proliferation in pancreatic adenocarcinoma.

Expression pattern of aquaporins in patients with primary nephrotic syndrome with edema.

Analysis of the differential expression of circulating microRNAs during the progression of hepatic fibrosis in patients with chronic hepatitis B virus infection.

Colchicine induces apoptosis in HT29 human colon cancer cells via the AKT and c-Jun N-terminal kinase signaling pathways.

Upregulation of the gene expression of CLOCK is correlated with hypoxia-inducible factor 1 in advanced varicose lesions.

Peroxisome proliferator-activated receptor-Î³ inhibits pancreatic cancer cell invasion and metastasis via regulating MMP-2 expression through PTEN.

Distribution and effect of steroidal saponin derivative WRC3 in B16 melanoma cells.

Catabolite control protein A has an important role in the metabolic regulation of Streptococcus suis type 2 according to iTRAQ-based quantitative proteomic analysis.

Inhibition of microRNA-30a prevents puromycin aminonucleoside-induced podocytic apoptosis by upregulating the glucocorticoid receptor .

Silica promotes the transdifferentiation of rat circulating fibrocytes in vitro.

Epigallocatechin3gallate inhibits the invasion of salivary adenoid cystic carcinoma cells by reversing the hypermethylation status of the RECK gene.

Extract of Rhizoma Polygonum cuspidatum reduces early renal podocyte injury in streptozotocininduced diabetic rats and its active compound emodin inhibits methylglyoxalmediated glycation of proteins.

Twogene mutation in a single patient: Biochemical and functional analysis for a correct interpretation of exome results.

Polyphenolic composition of grape stem extracts affects antioxidant activity in endothelial and muscle cells

DAL-1/4.1B contributes to epithelial-mesenchymal transition via regulation of transforming growth factor-ß in lung cancer cell lines.

Endosialinexpressing bone sarcoma stemlike cells are highly tumorinitiating and invasive.

Baicalin alleviates diabetesassociated cognitive deficits via modulation of mitogen-activated protein kinase signaling, brainderived neurotrophic factor and apoptosis.

Epirubicin inhibits growth and alters the malignant phenotype of the U87 glioma cell line.

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Synergistic effect of a tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 coexpression vector on the proliferation of rat vascular smooth muscle cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yu, Huizhen Huang, Shujie Li, Feng Zhu, Pengli Xiang, Hong Zheng, Weiping
Description	Author Affiliation: Zhu P ( Department of Geriatrics, Fujian Provincial Hospital Key Laboratory of Geriatrics, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.); Yu H ( Department of Geriatrics, Fujian Provincial Hospital Key Laboratory of Geriatrics, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.); Huang S ( Department of Cardiology, Fujian Provincial Hospital, Fuzhou, Fujian 350001, P.R. China.); Xiang H ( Department of Geriatrics, Fujian Provincial Hospital Key Laboratory of Geriatrics, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.); Li F ( Department of Geriatrics, Fujian Provincial Hospital Key Laboratory of Geriatrics, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.); Zheng W ( Department of Geriatrics, Fujian Provincial Hospital Key Laboratory of Geriatrics, Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.)
Abstract	Tissue kallikrein 1 (TK1) and tissue inhibitor of matrix metalloproteinase 1 (TIMP1) are important in inhibiting vascular smooth muscle cell (VSMC) proliferation and improving vascular remodeling, respectively. It was hypothesized that a combination of TK1 and TIMP1 genes, mediated by an adenovirus vector could augment or act in synergy to enhance the inhibitory effects. The promoter, mCMV carrying hTIMP1 cDNA was subcloned into pDC316hTK1 to construct a recombinant plasmid carrying hTK1 and hTIMP1 genes. Subsequently, the double gene plasmid and adenovirus backbone plasmid were packaged into HEK293A cells. Gene transcription and protein expression were examined, respectively using reverse transcriptionquantitative polymerase chain reaction (PCR) and western blotting assays. VSMC proliferation was assessed using cell counting and methylthiazolyltetrazoliuin methods. The constructed plasmid containing hTK1 and hTIMP1 genes was correctly identified by means of PCR, double digestion and sequencing analysis. The coexpression vector, AdhTK1hTIMP1 was successfully constructed and packaged into HEK293A cells. When VSMCs were transfected with the coexpression vector, the mRNA transcription and protein expression of hTK1 and hTIMP1 exhibited abundant expression in a concentrationdependent and timedependent manner, independently. In conclusion, the coexpression vector synergistically inhibited the cell growth and proliferation induced by plateletderived growth factorBB compared with the single gene vector.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2015.4198
Journal	Molecular Medicine Reports
Issue Number	4
Volume Number	12
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-10-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Genetic Vectors Metabolism Plasmids Tissue Inhibitor Of Metalloproteinase-1 Genetics Tissue Kallikreins Adenoviridae Animals Aorta Cytology Drug Effects Cell Culture Techniques Cell Proliferation Gene Expression Chemistry Hek293 Cells Molecular Sequence Data Muscle, Smooth, Vascular Myocytes, Smooth Muscle Proto-oncogene Proteins C-sis Pharmacology Rats, Sprague-dawley Transfection Transgenes Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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