NDLI: Tumor suppressor microRNA-18a regulates tumor proliferation and invasion by targeting TBPL1 in colorectal cancer cells.

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Tumor suppressor microRNA-18a regulates tumor proliferation and invasion by targeting TBPL1 in colorectal cancer cells.

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Luteolin-induced protection of H2O2-induced apoptosis in PC12 cells and the associated pathway.

Effects of highmobility group box 1 knockdown on proliferation, migration and invasion of the HONE1 human nasopharyngeal carcinoma cell line.

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Rhoassociated kinase inhibitor, Y27632, inhibits the invasion and proliferation of T24 and 5367 bladder cancer cells.

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Investigation into hippocampal nerve cell damage through the mineralocorticoid receptor in mice.

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[Corrigendum] Activation of sonic hedgehog signaling enhances cell migration and invasion by induction of matrix metalloproteinase-2 and -9 via the phosphoinositide-3 kinase/AKT signaling pathway in glioblastoma.

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Pseudolaric acid B inhibits proliferation in SW579 human thyroid squamous cell carcinoma.

Curcumin induces p53-independent necrosis in H1299 cells via a mitochondria-associated pathway.

Role of microRNA503 in the suppression of osteosarcoma cell proliferation and migration via modulation of fibroblast growth factor 2.

MicroRNA3615p suppresses cancer progression by targeting signal transducer and activator of transcription 6 in nonsmall cell lung cancer.

Isorhamnetin inhibits cell proliferation and induces apoptosis in breast cancer via Akt and mitogenactivated protein kinase kinase signaling pathways.

DNA methylation patterns of protein-coding genes and long non-coding RNAs in males with schizophrenia.

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Tumor suppressor microRNA-18a regulates tumor proliferation and invasion by targeting TBPL1 in colorectal cancer cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liu, Yuanhua Yang, Zhen Wang, Junxia Liu, Guanghui Li, Dongyan Zhang, Xiefu
Description	Author Affiliation: Liu G ( Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.); Liu Y ( Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.); Yang Z ( Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.); Wang J ( Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.); Li D ( Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.); Zhang X ( Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.)
Abstract	Recent advances in the understanding of microRNA have rendered microRNAs (miRNAs) a compelling novel class of biomarker in cancer biology. However, the specific function of miRNA18a (miR18a) in colorectal cancer (CRC) remains unclear. In the present study, the role of miR18a in the carcinogenesis of CRC was investigated. miR18a expression was assessed in CRC specimens and cell lines using reverse transcriptionquantitative polymerase chain reaction (RTqPCR). The targets of miR18a were predicted using bioinformatics tools. Luciferase reporter assays were used to confirm the functional association between miR18a and its target genes. The effect of miR18a on cell proliferation, invasion and migration was confirmed in vitro by a methylthiazol tetrazolium assay, cell invasion assay, and wound healing assay. Gene and protein expression was examined using RTqPCR and western blotting, respectively. It was demonstrated that the expression of miR18a in CRC tissues and cell lines was markedly lower than in normal control tissues and cells, respectively. In addition, miR18a inhibited cell proliferation, invasion and migration in CRC cells. Moreover, TATA boxbinding proteinlike protein 1 (TBPL1) was identified as a potential target gene of miR18a in the bioinformatics analysis and luciferase reporter assays, and miR18a directly inhibited TBPL1 expression by targeting its 3'untranslated region. Furthermore, TBPL1 was downregulated and inversely correlated with miR18a expression in tissues. These findings demonstrate that miR18a exhibits a protective role in CRC via inhibiting proliferation, invasion and migration of CRC cells by directly targeting the TBPL1 gene.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	5
Volume Number	12
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-11-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Colon Pathology Colorectal Neoplasms Genetics Gene Expression Regulation, Neoplastic Micrornas Tata Box Binding Protein-like Proteins Carcinogenesis Cell Line, Tumor Cell Proliferation Metabolism Genes, Tumor Suppressor Neoplasm Invasiveness Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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