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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gao, Yuan Chen, Keen Guo, Guoqing Gong, Xiaobing Tan, Minghui |
| Description | Author Affiliation: Gong X ( Department of Gastroenterology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, P.R. China.); Tan M ( Department of Anatomy, Medical College of Jinan University, Guangzhou, Guangdong 510630, P.R. China.); Gao Y ( Department of Gastroenterology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, P.R. China.); Chen K ( Department of Anatomy, Medical College of Jinan University, Guangzhou, Guangdong 510630, P.R. China.); Guo G ( Department of Anatomy, Medical College of Jinan University, Guangzhou, Guangdong 510630, P.R. China.) |
| Abstract | CRMP family proteins (CRMPs) are abundantly expressed in the developing nervous system mediating growth cone guidance, neuronal polarity and axon elongation. CRMP5 has been indicated to serve a critical role in neurite outgrowth. However, the detailed mechanisms of how CRMP5 regulates neurite outgrowth remain unclear. In the current study, co-immunoprecipitation was used to identify the fact that CRMP5 interacted with the actin and tubulin cytoskeleton networks in the growth cones of developing hippocampal neurons. CRMP5 exhibited increased affinity towards actin when compared with microtubules. Immunocytochemistry was used to identify the fact that CRMP5 colocalized with actin predominantly in the C-domain and T-zone in growth cones. In addition, genetic inhibition of CRMP5 by siRNA suppressed the expression of actin, growth cone development and neurite outgrowth. Overexpression of CRMP5 promoted the interaction with actin, growth cone development and hippocampal neurite outgrowth. Taken together, these data suggest that CRMP5 is able to interact with the actin cytoskeleton network in the growth cone and affect growth cone development and neurite outgrowth via this interaction in developing hippocampal neurons. |
| ISSN | 17912997 |
| e-ISSN | 17913004 |
| DOI | 10.3892/mmr.2015.4662 |
| Journal | Molecular Medicine Reports |
| Issue Number | 2 |
| Volume Number | 13 |
| Language | English |
| Publisher | Spandidos Publications |
| Publisher Date | 2016-02-01 |
| Publisher Place | Greece |
| Access Restriction | Open |
| Subject Keyword | Actins Metabolism Adaptor Proteins, Signal Transducing Nerve Tissue Proteins Neurites Animals Cytoskeleton Growth Cones Hek293 Cells Protein Binding Rats, Sprague-dawley Research Support, Non-u.s. Gov't Discipline Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology |
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