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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Luo, Jianmin Feng, Nan Guo, Ximin |
| Description | Author Affiliation: Feng N ( Department of Hematology, The Second Hospital of Hebei Medical University, Shijiazhuan, Hebei 050000, P.R. China.); Luo J ( Department of Hematology, The Second Hospital of Hebei Medical University, Shijiazhuan, Hebei 050000, P.R. China.); Guo X ( Academy of Military Medical Sciences of the Chinese PLA, Beijing 100850, P.R. China.) |
| Abstract | Silybin is a biologically active component extracted from the seeds of Silybum marianum, which has been shown to have inhibitory effects on prostate, skin, bladder, lung and colon cancer cells, in addition to its efficacy in the treatment of liver diseases, including hepatitis and cirrhosis. The aim of the present study was to investigate whether silybin suppresses the proliferation and induces apoptosis of multiple myeloma (MM) cells and to elucidate its molecular targets. The proliferative and apoptotic rates of the U266 MM cell line were assessed using MTT and flowcytometric assays, respectively. Western blot analysis was used to assess the protein levels of phosphoinositide3 kinase (PI3K), phosphorylated (p)Akt and pmammalian target of rapamycin (mTOR) in U266 cells. In addition, PI3K inhibitor LY294002 or activator insulinlike growth factor 1 were used to investigate the involvement of the PI3K/AktmTOR signaling pathway in the effect of silybin on U266 cells. The results revealed that silybin restrained the proliferation and enhanced the apoptosis of U266 cells. Furthermore, silybin inhibited the protein expression of PI3K, pAkt and pmTOR in U266 cells. Of note, inhibition of PI3K facilitated silybinmediated reduction of mTOR activation, cell proliferation and induction of apoptosis in U266 cells, while activation of PI3K attenuated the effects of silybin. In conclusion, silybin suppressed cell proliferation and promoted apoptosis of U266 cells via PI3K/Akt-mTOR signaling pathways. |
| ISSN | 17912997 |
| e-ISSN | 17913004 |
| Journal | Molecular Medicine Reports |
| Issue Number | 4 |
| Volume Number | 13 |
| Language | English |
| Publisher | Spandidos Publications |
| Publisher Date | 2016-04-01 |
| Publisher Place | Greece |
| Access Restriction | Open |
| Subject Keyword | Discipline Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology |
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