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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yang, Mei Segal, Neil A. Nevitt, Michael Felson, David T. Torner, James C. Lewis, Cora E. Glass, Natalie A. Hurley, Michael |
| Spatial Coverage | United States |
| Description | Country affiliation: United States Author Affiliation: Segal NA ( Departments of Orthopaedics and Rehabilitation, Radiology, and Epidemiology, The University of Iowa, Iowa City, IA 52242-1088, USA. segal-research@uiowa.edu) |
| Abstract | PURPOSE: Impaired quadriceps strength and joint position sense (JPS) have been linked with knee osteoarthritis (OA) cross-sectionally. Although neither has been independently associated with incident radiographic OA, their combination may mediate risk. The purpose of this study was to determine whether better sensorimotor function protects against the development of incident radiographic or symptomatic knee OA. METHODS: The Multicenter Osteoarthritis study is a longitudinal study of adults aged 5079 yr at high risk for knee OA. Participants underwent bilateral, weight-bearing, fixed-flexion radiographs, JPS acuity tests, and isokinetic quadriceps strength tests. The relationships between combinations of the tertiles of sex-specific baseline peak strength and mean JPS and development of incident radiographic (KellgrenLawrence (KL) grade Q2) or symptomatic knee OA (KL grade Q2 and frequent knee pain or stiffness) at a 30-month follow-up were evaluated. Secondary analyses defined JPS as the variance during the 10 JPS trials and also assessed the interaction of strength and JPS in predicting each outcome. RESULTS: The study of incident radiographic knee OA included 1390 participants (age = 61.2 ± 7 .9 yr and body mass index = 29.4 ± 5.1 kg·m−²), and the study of incident symptomatic knee OA included 1829 participants (age = 62.2 ± 8.0 yr and body mass index = 30.0 ± 5.4 kg·m−²). Greater strength at baseline protected against incident symptomatic but not radiographic knee OA regardless of JPS tertile. There was no significant relationship between the strengthJPS interaction and the development of radiographic or symptomatic knee OA. CONCLUSIONS: The finding that quadriceps strength protected against incident symptomatic but not radiographic knee OA regardless of JPS tertile suggests that strength may be more important than JPS in mediating risk for knee OA. |
| ISSN | 01959131 |
| e-ISSN | 15300315 |
| DOI | 10.1249/MSS.0b013e3181dd902e |
| Journal | Medicine & Science in Sports & Exercise |
| Issue Number | 11 |
| Volume Number | 42 |
| Language | English |
| Publisher | Lippincott Williams & Wilkins (on behalf of the American College of Sports Medicine) |
| Publisher Date | 2010-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Muscle Strength Physiology Osteoarthritis, Knee Etiology Proprioception Quadriceps Muscle Longitudinal Studies Risk Assessment Multicenter Study Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Sports Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Physical Therapy, Sports Therapy and Rehabilitation Sports Science |
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