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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jacob-Filho, Wilson Mendes, Felipe Augusto Rodrigues Cukier, Alberto Stelmach, Rafael Carvalho, Celso Ricardo Fernandes Almeida, Francine Maria Martins, Milton A. |
| Description | Country affiliation: Brazil Author Affiliation: Mendes FA ( Department of Physical Therapy, School of Medicine, University of São Paulo, São Paulo, BRAZIL.) |
| Abstract | PURPOSE: there is evidence suggesting that physical activity has anti-inflammatory effects in many chronic diseases; however, the role of exercise in airway inflammation in asthma is poorly understood. We aimed to evaluate the effects of an aerobic training program on eosinophil inflammation (primary aim) and nitric oxide (secondary aim) in patients with moderate or severe persistent asthma. METHODS: sixty-eight patients randomly assigned to either control (CG) or aerobic training (TG) groups were studied during the period between medical consultations. Patients in the CG (educational program + breathing exercises; N = 34) and TG (educational program + breathing exercises + aerobic training; N = 34) were examined twice a week during a 3-month period. Before and after the intervention, patients underwent induced sputum, fractional exhaled nitric oxide (FeNO), pulmonary function, and cardiopulmonary exercise testing. Asthma symptom-free days were quantified monthly, and asthma exacerbation was monitored during 3 months of intervention. RESULTS: at 3 months, decreases in the total and eosinophil cell counts in induced sputum (P = 0.004) and in the levels of FeNO (P = 0.009) were observed after intervention only in the TG. The number of asthma symptom-free days and VO(2max) also significantly improved (P < 0.001), and lower asthma exacerbation occurred in the TG (P < 0.01). In addition, the TG presented a strong positive relationship between baseline FeNO and eosinophil counts as well as their improvement after training (r = 0.77 and r = 0.9, respectively). CONCLUSIONS: aerobic training reduces sputum eosinophil and FeNO in patients with moderate or severe asthma, and these benefits were more significant in subjects with higher levels of inflammation. These results suggest that aerobic training might be useful as an adjuvant therapy in asthmatic patients under optimized medical treatment. |
| ISSN | 01959131 |
| Issue Number | 2 |
| Volume Number | 43 |
| e-ISSN | 15300315 |
| Journal | Medicine & Science in Sports & Exercise |
| Language | English |
| Publisher | Lippincott Williams & Wilkins (on behalf of the American College of Sports Medicine) |
| Publisher Date | 2011-02-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Asthma Physiopathology Therapy Exercise Physiology Adult Diagnostic Techniques, Cardiovascular Eosinophils Exercise Test Methods Female Humans Male Middle Aged Nitric Oxide Metabolism Oxygen Consumption Respiratory Function Tests Respiratory System Sputum Young Adult Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't Discipline Sports Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Physical Therapy, Sports Therapy and Rehabilitation Sports Science |
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