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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Huebschmann, Amy G. Regensteiner, Judith G. Herlache, Leah Bauer, Timothy A. Wolfel, Eugene E. Weinberger, Howard D. Reusch, Jane E. B. |
| Description | Country affiliation: Colombia Author Affiliation: Regensteiner JG ( 1Department of Medicine, Division of Internal Medicine, University of Colorado School of Medicine, Aurora, CO) |
| Abstract | PURPOSE: People with uncomplicated type 2 diabetes (T2D) have impaired peak exercise performance compared with that of their nondiabetic counterparts. This impairment may represent the earliest indication of cardiovascular (CV) abnormalities in T2D. Women with T2D are known to have worse CV outcomes than those in men with T2D. We hypothesized that women with diabetes have a greater exercise impairment than that in men with diabetes compared with that in their nondiabetic counterparts. METHODS: We studied 15 women (premenopausal) and 14 men with T2D as well as their nondiabetic counterparts (22 women and 13 men). Exercise testing was performed. Additional outcomes included measurements of insulin sensitivity, endothelial function, blood flow, and resting cardiac function. RESULTS: Men and women with T2D but not controls had impaired insulin sensitivity. Women with T2D had a lower peak oxygen consumption (VË O2peak) compared with that of nondiabetic women (24%, P < 0.05) than men with diabetes compared with that in nondiabetic men (16%, P < 0.05) (P value between groups < 0.05). The time constants (phase 2) of the VË O2 kinetic response tended to be slower in men and women with T2D than those in nondiabetic controls (P = 0.08). There were no differences in resting ventricular function by Doppler echocardiography techniques between groups. Women with T2D had significantly lower flow-mediated dilation and blood flow responses to hyperemia than those in nondiabetic women (both P < 0.05), whereas men with T2D had lower flow-mediated dilation but not lower blood flow than those in nondiabetic men. CONCLUSIONS: Although both men and women with uncomplicated T2D had a lower VË O2peak, the abnormality in women with T2D compared with that in nondiabetic women was greater than that seen in men. Because VË O2peak has a strong inverse correlation with mortality, sex disparities observed in exercise capacity among people with T2D suggest a possible rationale for the increased CV morbidity and mortality observed in women compared with those observed in men with uncomplicated T2D. |
| ISSN | 01959131 |
| e-ISSN | 15300315 |
| DOI | 10.1249/MSS.0000000000000371 |
| Journal | Medicine & Science in Sports & Exercise |
| Issue Number | 1 |
| Volume Number | 47 |
| Language | English |
| Publisher | Lippincott Williams & Wilkins (on behalf of the American College of Sports Medicine) |
| Publisher Date | 2015-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Diabetes Mellitus, Type 2 Physiopathology Physiology Sex Factors Brachial Artery Echocardiography, Doppler Endothelium Forearm Blood Supply Healthy Volunteers Insulin Resistance Kinetics Oxygen Consumption Reaction Time Regional Blood Flow Vasodilation Ventricular Function Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Sports Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Physical Therapy, Sports Therapy and Rehabilitation Sports Science |
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