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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cho, Young Joo Kim, Eung Kweon Lee, Hyung Keun |
| Description | Responsible library: WPRO |
| Abstract | PURPOSE: To investigate the effect of low-dose systemic cyclosporine A (CsA) in preventing graft failure after high-risk penetrating keratoplasty (PKP). METHODS: In this retrospective study, 36 eyes of 25 patients who underwent PKP were evaluated. At 24 months postoperatively, the failure rate in the CsA group (n = 19) was compared to the control group (n = 17). For subgroup analysis, the failure rate in the CsA group (n = 9) and control group (n = 9) was compared in patients who underwent a repeat PKP. The patients' side-effect profile was also collected. RESULTS: The median follow-up in the CsA group was 32.8 months and 28.9 months in the control group. Graft failure occurred in 31.6% CsA patients and in 68.4% control patients (p = 0.311). In patients with repeat PKP, the failure rate in the CsA group was significantly lower than the control group (22.2% vs. 77.8%, p = 0.018). In one case (5.26%), CsA was discontinued due to gastroinstestinal discomfort. CONCLUSIONS: Low-dose CsA was not beneficial compared to conventional therapy in high-risk PKP patients. However, in the repeat PKP subgroup, the incidence of graft failure was lower with low-dose CsA than with conventional therapy. Although further study is necessary, adding low-dose CsA might be beneficial for repeat PKP patients. |
| ISSN | 03786471 |
| e-ISSN | 20922374 |
| Journal | Journal of the Korean Ophthalmological Society |
| Issue Number | 1 |
| Volume Number | 55 |
| Language | Korean |
| Publisher | The Korean Ophthalmological Society |
| Publisher Date | 2014-01-01 |
| Publisher Place | Korea (South) |
| Access Restriction | Open |
| Subject Keyword | Cyclosporine Keratoplasty, Penetrating Retrospective Studies Transplants Original Article Discipline Ophthalmology Discipline Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology |
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