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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Weiner, W. J. Klawans, H. L. |
| Abstract | Lumbar cerebrospinal fluid homovanillic acid levels were estimated in 60 patients with Parkinsonism before and during levodopa treatment. There was a slight negative correlation between pretreatment CSF homovanillic acid levels and disability. There was no correlation between pretreatment homovanillic acid levels and clinical response to levodopa. Patients with high pretreatment levels did as well as those with depressed levels. High (normal or near normal) levels of CSF homovanillic acid in a patient with Parkinsonism do not necessarily indicate that the Parkinsonism will not respond to levodopa. These patients should receive the benefit of a trial of levodopa. There was also no correlation between homovanillic acid level during tratment and improvement. Patients with minimal increases in CSF homovanillic acid responded as well as those with greater elevations. Failure of levodopa to increase CSF homovanillic acid significantly does not indicate that the patient will not respond to levodopa and that levodopa should be discontinued. Other factors, such as vitamin B(6) consumption, should be investigated. |
| ISSN | 00223050 |
| e-ISSN | 1468330X |
| Journal | Journal of Neurology, Neurosurgery & Psychiatry |
| Issue Number | 5 |
| Volume Number | 36 |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Date | 1973-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Dihydroxyphenylalanine Therapeutic Use Parkinson Disease Drug Therapy Phenylacetates Cerebrospinal Fluid Disability Evaluation Evaluation Studies As Topic Homovanillic Acid Prognosis Discipline Neurology Discipline Neurosurgery Discipline Psychiatry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology (clinical) Surgery Psychiatry and Mental Health |
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