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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Z'Graggen, W. J. Magistris, M. R. Rösler, K. M. Humm, A. M. Bühler, R. |
| Description | Country affiliation: Switzerland Author Affiliation: Humm AM ( Department of Neurology, University of Berne, Switzerland.) |
| Abstract | OBJECTIVE: To compare the effects of intravenous methylprednisolone (IVMP) in patients with relapsing-remitting (RR-MS), secondary progressive (SP-MS), and primary progressive multiple sclerosis (PP-MS). METHODS: Clinical and neurophysiological follow up was undertaken in 24 RR-MS, eight SP-MS, and nine PP-MS patients receiving Solu-Medrol 500 mg/d over five days for exacerbations involving the motor system. Motor evoked potentials (MEPs) were used to measure central motor conduction time (CMCT) and the triple stimulation technique (TST) was applied to assess conduction deficits. The TST allows accurate quantification of the number of conducting central motor neurones, expressed by the TST amplitude ratio. RESULTS: There was a significant increase in TST amplitude ratio in RR-MS (p<0.001) and SP-MS patients (p<0.02) at day 5, paralleling an increase in muscle force. TST amplitude ratio and muscle force remained stable at two months. In PP-MS, TST amplitude ratio and muscle force did not change. CMCT did not change significantly in any of the three groups. CONCLUSIONS: In RR-MS and SP-MS, IVMP is followed by a prompt increase in conducting central motor neurones paralleled by improvement in muscle force, which most probably reflects partial resolution of central conduction block. The lack of similar clinical and neurophysiological changes in PP-MS corroborates previous clinical reports on limited IVMP efficacy in this patient group and points to pathophysiological differences underlying exacerbations in PP-MS. |
| ISSN | 00223050 |
| e-ISSN | 1468330X |
| Journal | Journal of Neurology, Neurosurgery & Psychiatry |
| Issue Number | 3 |
| Volume Number | 77 |
| Language | English |
| Publisher | BMJ Publishing Group Ltd. |
| Publisher Date | 2006-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Methylprednisolone Therapeutic Use Motor Neuron Disease Drug Therapy Multiple Sclerosis, Chronic Progressive Multiple Sclerosis, Relapsing-remitting Neural Conduction Drug Effects Dose-response Relationship, Drug Evoked Potentials, Motor Physiology Infusions, Intravenous Isometric Contraction Adverse Effects Physiopathology Diagnosis Muscle, Skeletal Optic Neuritis Pyramidal Tracts Comparative Study Research Support, Non-u.s. Gov't Discipline Neurology Discipline Neurosurgery Discipline Psychiatry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology (clinical) Surgery Psychiatry and Mental Health |
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