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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hao, Fang Lu, Dawei Liu, Rutao Zhao, Xingchen |
| Description | Author Affiliation: Zhao X ( State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China.); Lu D ( State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China.); Hao F ( State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China.); Liu R ( Shandong Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, China-America CRC for Environment & Health, Jinan 250100, PR China. Electronic address: rutaoliu@sdu.edu.cn.) |
| Abstract | In this work, we investigated and compared carbon nanotubes (CNTs) of different diameters regarding their interaction with bovine serum albumin (BSA) and their ability to alter protein structure. BSA was exposed to CNT solutions, and the effects were assessed by utilizing fluorescence spectroscopy, UV-vis absorption spectroscopy, circular dichroism (CD) spectroscopy, transmission electron microscopy (TEM), bichinchoninic acid (BCA) and zeta-potential measurement assays. We demonstrate that CNT diameter and surface area play key roles in influencing the stability of adsorbed proteins. Results showed that the secondary and tertiary structural stability of BSA decreased upon adsorption onto CNTs, with greater decrease on smaller-diametered nanotubes. Besides, more protein was loaded onto CNTs with small diameter, reducing the cytotoxicity. This study, therefore, provides fundamental information for the influence of CNT diameter and surface on protein behavior, which may be helpful to understand toxic effects of CNTs and prove beneficial for developing novel biomedical devices and safe use of nanomaterials. |
| ISSN | 03043894 |
| Volume Number | 292 |
| e-ISSN | 18733336 |
| Journal | Journal of Hazardous Materials |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-07-15 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Nanotubes, Carbon Toxicity Circular Dichroism Microscopy, Electron, Transmission Molecular Conformation Spectrometry, Fluorescence Spectrum Analysis Methods Surface Properties Journal Article Research Support, Non-u.s. Gov't Discipline Environmental Science Discipline Environmental Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Environmental Chemistry Pollution Waste Management and Disposal Health, Toxicology and Mutagenesis Environmental Engineering |
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