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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shi, Zhi-guo Xu, Li Hu, Min Li, Jian |
| Description | Country affiliation: China Author Affiliation: Li J ( Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China.); Xu L ( Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China.); Shi ZG ( Department of Chemistry, Wuhan University, Wuhan 430072, China. Electronic address: shizg@whu.edu.cn.); Hu M ( Hubei Instrument for Food and Drug Control, Wuhan, China.) |
| Abstract | In this study, a novel two-dimensional liquid chromatographic (2D-LC) system was developed for simultaneous separation and toxicity prediction of pharmaceutical and its related substances. A conventional ODS column was used on the 1st-D to separate the sample; while, bio-partitioning micellar chromatography served as the 2nd-D to predict toxicity of the components. The established system was tested for the toxicity of ibuprofen and its impurities with known toxicity. With only one injection, ibuprofen and its impurities were separated on the 1st-D; and LC50 values of individual impurity were obtained based on the quantitative retention-activity relationships, which agreed well with the reported data. Furthermore, LC50 values of photolysis transformation products (TPs) of carprofen, ketoprofen and diclofenac acid (as unknown compounds) were screened in this 2D-LC system, which could be an indicator of the toxicity of these TPs and was meaningful for the environmental monitoring and drinking water treatment. The established 2D-LC system was cost-effective, time-saving and reliable, and was promising for fast online screening of toxicity of known and unknown analytes in the complex sample in a single step. It may find applications in environment, pharmaceutical and food, etc. |
| ISSN | 03043894 |
| Volume Number | 293 |
| e-ISSN | 18733336 |
| Journal | Journal of Hazardous Materials |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-08-15 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Anti-inflammatory Agents, Non-steroidal Chemistry Toxicity Drug-related Side Effects And Adverse Reactions Models, Biological Pharmaceutical Preparations Animals Carbazoles Chlorophyta Drug Effects Chromatography, Liquid Methods Computer Simulation Daphnia Diclofenac Drug Contamination Fishes Ibuprofen Ketoprofen Lethal Dose 50 Photolysis Journal Article Research Support, Non-u.s. Gov't Discipline Environmental Science Discipline Environmental Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Environmental Chemistry Pollution Waste Management and Disposal Health, Toxicology and Mutagenesis Environmental Engineering |
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