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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hong, Qing Wang, Xiang Zhu, Shijun Hu, Gang Wang, Hui Zhang, Chenfei Zhang, Yingkun Jin, Wen Hu, Bo |
| Description | Author Affiliation: Zhang Y ( Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of life sciences, Nanjing Agricultural University, Nanjing, 210095, PR China.); Wang H ( Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of life sciences, Nanjing Agricultural University, Nanjing, 210095, PR China.); Wang X ( Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of life sciences, Nanjing Agricultural University, Nanjing, 210095, PR China.); Hu B ( Industrial Product Division, Intrexon Corporation, South San Francisco, CA, 94080, USA.); Zhang C ( Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of life sciences, Nanjing Agricultural University, Nanjing, 210095, PR China.); Jin W ( Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of life sciences, Nanjing Agricultural University, Nanjing, 210095, PR China.); Zhu S ( Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of life sciences, Nanjing Agricultural University, Nanjing, 210095, PR China.); Hu G ( Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of life sciences, Nanjing Agricultural University, Nanjing, 210095, PR China); Hong Q ( Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of life sciences, Nanjing Agricultural University, Nanjing, 210095, PR China. Electronic address: hongqing@njau.edu.cn.) |
| Abstract | A novel carbendazim (methyl-1H-benzimidazol-2-ylcarbamate, or MBC) degrading strain SD-4 was isolated and identified preliminarily as Mycobacterium sp. according to its phenotypic features and phylogenetic analysis. This strain could utilize MBC as the sole carbon and nitrogen sources for growth and degrade 50mgL MBC at the average degradation rate of 0.63mgL h . Strain SD-4 degraded MBC through the typical pathway, in which MBC was first hydrolyzed by MheI to 2-aminobenzimidazole (2-AB) and then converted to 2-hydroxybenzimidazole (2-HB). The MBC hydrolase encoding gene mheI was cloned from strain SD-4 and successfully expressed in Escherichia coli by codon optimization. The sulfhydryl-blocking assay revealed that the activity of MheI was closely related to cysteine, and the site-directed mutation experiment showed that Cys16 and Cys222 played important roles during the hydrolysis of MBC by MheI. Therefore they affected its activity directly and were defined as the key amino acid sites. |
| ISSN | 03043894 |
| Journal | Journal of Hazardous Materials |
| Volume Number | 331 |
| e-ISSN | 18733336 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2017-02-16 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Science Discipline Environmental Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Environmental Chemistry Pollution Waste Management and Disposal Health, Toxicology and Mutagenesis Environmental Engineering |
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