NDLI: Force-induced craniosynostosis via paracrine signaling in the murine sagittal suture.

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Force-induced craniosynostosis via paracrine signaling in the murine sagittal suture.

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Force-induced craniosynostosis via paracrine signaling in the murine sagittal suture.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Goldstein, Steven A. Oppenheimer, Adam J. Rhee, Samuel T. Buchman, Steven R.
Description	Country affiliation: United States Author Affiliation: Oppenheimer AJ ( Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.)
Abstract	INTRODUCTION: The role of genetic phenomena has been given central importance in the development of craniosynostosis. Proponents have dismissed the role of force as a key etiologic factor. Nonetheless, compressive forces on the developing calvarium have been shown to result in premature suture fusion. The purpose of this study was to determine whether cyclical loading of the murine calvarium could induce suture fusion in cocultured calvarial specimens. MATERIALS AND METHODS: Calvarial coupons from postnatal day 21, B6CBA wild-type mice (n = 24) were harvested and cultured. A custom appliance capable of delivering compressive loads was applied perpendicular to the sagittal suture in vitro. Six coupons were subjected to 0.3 g of force for 30 minutes each day for a total of 14 days. Six additional coupons were cocultured within the same medium. Control groups were devised. Histologic analysis of suture phenotype was performed. RESULTS: Sagittal sutures cocultured with unloaded specimens remained patent. In contradistinction, 4 of 6 specimens cocultured with loaded coupons demonstrated craniosynostosis (P = 0.03). Increased osteoid, alkaline phosphatase staining, and bone sialoprotein expression were observed when compared with matched controls. DISCUSSION: An in vitro model of force-induced craniosynostosis via paracrine effects has been devised. Premature fusion of the murine sagittal suture was induced in unloaded specimens cocultured with cyclically loaded calvarial coupons. These results implicate that abnormal forces may act through soluble factors to cause premature suture fusion in vitro. The findings support our global hypothesis that epigenetic phenomena play a crucial role in the pathogenesis of nonsyndromic craniosynostosis.
ISSN	10492275
Issue Number	2
Volume Number	23
e-ISSN	15363732
Journal	Journal of Craniofacial Surgery
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2012-03-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cranial Sutures Growth & Development Craniosynostoses Genetics Pathology Paracrine Communication Skull Alkaline Phosphatase Metabolism Animals Biological Markers Coculture Techniques Disease Models, Animal Integrin-binding Sialoprotein Mice Phenotype Stress, Mechanical Journal Article Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Medicine Discipline Otorhinolaryngology Discipline Surgery
Content Type	Text
Resource Type	Article
Subject	Otorhinolaryngology Surgery

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