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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Khaldi, Lubna Eleftheriadis, Iro Dontas, Ismene Leventis, Minas Eleftheriadis, Areti Faratzis, Gregory Chrysomali, Evanthia |
| Description | Country affiliation: Greece Author Affiliation: Faratzis G ( Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Athens, Greece.) |
| Abstract | PURPOSE: The aim of the study was to investigate the effect of autologous platelet-rich plasma (PRP) on the osteogenic potential of a biphasic synthetic graft material composed of hydroxyapatite and beta-tricalcium phosphate (HA/ß-TCP) in critical-size cranial defects in rabbits. MATERIALS AND METHODS: Three circular bicortical critical-size cranial defects were created in each of 18 rabbits. The first of the defects was grafted with autologous PRP and HA/ß-TCP, the second was grafted with HA/ß-TCP without PRP, and the third was left unfilled as a negative control. Animals were euthanized at 2, 4, and 6 weeks after surgery. Harvested tissue specimens were evaluated histologically and histomorphometrically. Several parameters associated with osteoclastic and osteoblastic activities were measured and calculated. The results were statistically analyzed using the 1-way analysis of variance statistical method. RESULTS: Histologic analysis of the samples showed bone tissue formation at all experimental sites including untreated control defects. A statistically significant difference in new bone formation between the defects treated with HA/ß-TCP + PRP and defects treated with HA/ß-TCP alone was not observed. Control untreated defects showed the greatest bone regeneration. CONCLUSIONS: In this animal model, autologous PRP had no effect on bone healing in addition to a biphasic HA/ß-TCP synthetic graft material after 2, 4, and 6 weeks of implantation. |
| ISSN | 10492275 |
| Issue Number | 5 |
| Volume Number | 23 |
| e-ISSN | 15363732 |
| Journal | Journal of Craniofacial Surgery |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2012-09-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Hydroxyapatites Pharmacology Osteogenesis Drug Effects Platelet-rich Plasma Skull Surgery Analysis Of Variance Animals Biocompatible Materials Rabbits Transplantation, Autologous Journal Article Discipline Medicine Discipline Otorhinolaryngology Discipline Surgery |
| Content Type | Text |
| Resource Type | Article |
| Subject | Otorhinolaryngology Surgery |
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